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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Sivakumar, D. Sivaraman, T. |
| Copyright Year | 2012 |
| Description | Author affiliation: Structural Biology Lab, Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA University, Thanjavur-613401, Tamil Nadu, India (Sivakumar, D.; Sivaraman, T.) |
| Abstract | Anti-apoptotic proteins such as Bcl-XL and Mcl-1 have been reported to be over expressed in most cancer forms and consequently, designing dual inhibitors to the proteins is becoming an important strategy in cancer chemotherapy. Interestingly, the Bcl-XL and Mcl-1 show differential binding affinities with BH3-only peptides of Bim and NOXA, notwithstanding their similar three-dimensional folds. The structural determinants for the differential interactions of the proteins with the BH3-only peptides have been scrutinized using molecular docking and temperature-dependent dynamic studies. The comprehensive analysis of the data from the studies paved a way of designing dual inhibitors to the proteins, on the basis of the chemical structures of ABT-737, which is a highly potent inhibitor to the Bcl-XL. The unique feature of this approach on designing the dual inhibitors to the anti-apoptotic proteins have also been brought into detail through a comparative analysis with a few existing strategies reported on the same line in the literature |
| Starting Page | 174 |
| Ending Page | 178 |
| File Size | 865336 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781467302135 |
| e-ISBN | 9788190904223 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-03-30 |
| Publisher Place | India |
| Access Restriction | Subscribed |
| Rights Holder | Pillay Engineering College |
| Subject Keyword | Drugs Proteins Inhibitors Anti-apoptotic proteins Dual inhibitors In silico Robustness Macromolecular specificity Drug designing Chemicals |
| Content Type | Text |
| Resource Type | Article |
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