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Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Desrat, Sandy Remeur, Camille Roussi, Fanny |
| Copyright Year | 2015 |
| Abstract | The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer. These compounds were elaborated in ten linear steps. Their binding affinities for Bcl-xL and Mcl-1, two proteins of the Bcl-2 family, overexpressed in various types of cancers, were evaluated. This enabled to further SAR studies en route to the elaboration of potent dual inhibitors of anti-apoptotic proteins of the Bcl-2 family. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c5ob00354g |
| PubMed reference number | 25877523 |
| Journal | Medline |
| Volume Number | 13 |
| Issue Number | 19 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c5/ob/c5ob00354g/c5ob00354g1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c5ob00354g |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
