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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ahmad, Mohd Zulhelmy Hamid, Khuriah Abdul Effendi, Tommy Julianto Bustami |
| Copyright Year | 2012 |
| Description | Author affiliation: Faculty of Pharmacy, UiTM Puncak Alam, 42300, Bandar Puncak Alam, Selangor Malaysia (Ahmad, Mohd Zulhelmy; Hamid, Khuriah Abdul; Effendi, Tommy Julianto Bustami) |
| Abstract | Levodopa (l-dopa), the metabolic precursor of dopamine, has primarily been used for the treatment of Parkinson's disease (PD). A reversed phase high performance liquid chromatography (RP-HPLC) method with UV-detection at room temperature has been developed for analysis of levodopa. The method entailed direct injection of rat plasma sample after deproteinization using acetonitrile — propanol (1:1). The mobile phase comprises a mixture of water and acetonitrile containing 0.1% trifloroacetic acid. The flow rate was set at 1.0 ml/min with detector operating at 280nm and utilizes C18 (150 mm × 4.6 mm i.d. column) for the chromatographic separation. Under these conditions, the method was validated with respect to linearity, recovery, specificity, accuracy, precision, and stability. The described method was linear over a range of 0.39–200 μg/ml with mean correlation coefficient of 0.999. The percentage mean recovery was found to be 98.4%, while the coefficient of variation of within-day and between-day measurements were all less than 8%. The limit of quantification (LOQ) and limit of detection (LOD) of the method were 0.39 μg/ml and 0.19 μg/ml, respectively. This validated method was applied to determine the pharmacokinetic profiles of levodopa in rat plasma after its intestinal administration. |
| Starting Page | 134 |
| Ending Page | 139 |
| File Size | 272873 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781457716324 |
| e-ISBN | 9781457716348 |
| DOI | 10.1109/ISBEIA.2012.6422854 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-09-23 |
| Publisher Place | Indonesia |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Drugs Absorption Method validation Pharmacokinetic profiles Mobile communication Stability analysis Plasmas Levodopa Thermal stability Standards HPLC |
| Content Type | Text |
| Resource Type | Article |
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