NDLI: Expression of Amyloid-β peptide 42 in retinal ganglion cells of postnatal rats is light-exposure-dependent

Content Provider	IEEE Xplore Digital Library
Author	Chunfang Zhu Yirong Xu Peipei Zhang MinChen Wang Jun Liu Kaiyun Wu
Copyright Year	2010
Description	Author affiliation: Department of Anatomy, Medical College, Suzhou University, 215123 China (Chunfang Zhu; Yirong Xu; Peipei Zhang; MinChen Wang; Jun Liu) \|\| Department of Anatomy, Medical college, Soochow University, Suzhou, China (Kaiyun Wu)
Abstract	Aims: The aim of the present study was to investigate the expression of amyloid-β peptide 42 (Aβ-42) in retinal ganglion cells in postnatal rats. Sprague-Dawley rats were divided into 7 experimental groups: 3, 6, 13, 15, 25, 60, and 90 day postnatal groups. Rats from 15 and 25 day postnatal groups were further divided into light-exposure and non light-exposure group. Cryosections or flat-mounted retinas of rat eyes were used for immunocytochemistry staining for Aβ-42. Aβ-42 expression was not observed in rats within 13 days after birth, but was easily detectable in all groups of rats over 15 days after birth. In addition, the expression of Aβ-42 in retina was increasing as the rats got older, reached to highest level in 60 days after birth, and remained at that level even in 90 days after birth. Furthermore, the expression of Aβ-42 was not detected in rats kept under dark indicating that light is required for the expression of Aβ-42 in retina. This is the first report showing that normal retinal ganglion cells express Aβ-42, and that the expression of Aβ-42 in retinal ganglion cells requires the exposure to light. These data suggest that Aβ-42 may play a important role in vision development. The biological function and reglation of Aβ-42 in normal retinal ganglion cells require further investigation. Keywords- RMP, RPP5, Genomic DNA, cloning and characterization
Starting Page	382
Ending Page	385
File Size	350310
Page Count	4
File Format	PDF
ISBN	9781424467754
e-ISBN	9781424467754
DOI	10.1109/ICBBT.2010.5478934
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-04-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protocols Lightexposure dependent Peptides Rat Immunocytochemistry Rats Retina Educational institutions Anatomy Retinal ganglion cells Animals Cells (biology) Alzheimer's disease Immune system β-Amyloid peptide-42
Content Type	Text
Resource Type	Article

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