NDLI: Efficient and economical electro-drug delivery

Content Provider	IEEE Xplore Digital Library
Author	Sundararajan, R. Funian Xiao Lenarduzzi, N. Camarillo, I.G. Leary, J. Reese, L. Kumar, R. Muralitharen, S. Usman, S.M. Ramachandran, R.P. Cherian, K.M. Begam, S. Guhathakurta, S. Sankaranarayanan, K.
Copyright Year	2009
Description	Author affiliation: Crescent Engineering College, Chennai, India (Kumar, R.; Muralitharen, S.; Usman, S.M.; Ramachandran, R.P.) \|\| Purdue University, West Lafayette, In 47907 USA (Sundararajan, R.; Funian Xiao; Lenarduzzi, N.; Camarillo, I.G.; Leary, J.; Reese, L.) \|\| Frontier Lifeline, TICEL Biopark, Chennai, India (Cherian, K.M.; Begam, S.; Guhathakurta, S.; Sankaranarayanan, K.)
Abstract	Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma cells and also for delivering molecules into adult mesenchymal stem cells. Since current therapies do not work effectively for many patients, there is a need for alternative, affordable, yet effective treatments for various cancers and other diseases. For this purpose, electroporation, a pulse power technology was used as a tool to investigate its effect on viability and proliferation on human breast cancer cell lines and adult stem cells using various voltages and pulse durations. The results indicate that electrical pulses could be used effectively and economically to enhance drug transport across the normally impermeable plasma cell membranes as well as to reduce proliferation.
Starting Page	843
Ending Page	848
File Size	2014347
Page Count	6
File Format	PDF
ISBN	9781424438778
DOI	10.1109/TIC-STH.2009.5444382
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-26
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Pharmaceutical technology Medical treatment Humans Power generation economics Power system economics MCF-7 cells Electroporation Paclitaxel (Taxol) Breast cancer Diseases Bleomycin Voltage Stem cells Adult mesenchymal stem cell
Content Type	Text
Resource Type	Article

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