NDLI: Bioinformatics analysis the hub-proteins and co-expression proteins of lung squamous carcinoma and adenocarcinoma based on protein interaction network

Content Provider	IEEE Xplore Digital Library
Author	Chen Qi-long Qiao Zi-jun Yang He-jian Ni Teng-feng Chen Xiang-yang Chen Jian Hu Sheng Zheng Wen-Ling Ma Wen-Li
Copyright Year	2011
Description	Author affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou, 510515, China (Chen Jian; Hu Sheng; Zheng Wen-Ling; Ma Wen-Li) \|\| College of Life and Environment Science, Huangshan University, 245021, China (Chen Qi-long; Qiao Zi-jun; Yang He-jian; Ni Teng-feng; Chen Xiang-yang)
Abstract	Protein-protein interaction (PPI) networks provided valuable information for understanding the cellular function and biological processes. With the geometric increase in human protein interaction data, PPI network approach is significance to analyze the molecular mechanisms of disease, particularly to understand the phenomenon of carcinogenesis. In this study, the differentially expressed genes (DEGs) were mined from the data sets of lung squamous carcinoma and adenocarcinoma, respectively. The corresponding proteins of DEGs and cancer-related PPI pairs were search with related database,and then, the cancer-related PPI networks were constructed based on Cytoscape software. In order to elucidate the molecular mechanism of lung carcinogenesis from protein interaction levels, the characterizationsof hub proteins and hub co-expressed proteins of lung squamous carcinoma and adenocarcinoma were analyzed from cancer-related PPI networks. The results suggest that hub proteins more likely as Molecular Group approach to participate in lung carcinogenesis. Furthermore, hub co-expression proteins might act as evolutionary selection of biological processes of lung carcinogenesis, and theirs expressions and interactions are might related to poor prognosis in lung squamous carcinoma and adenocarcinoma.
Starting Page	256
Ending Page	261
File Size	299326
Page Count	6
File Format	PDF
ISBN	9781424487271
e-ISBN	9781424487288
DOI	10.1109/CSAE.2011.5952676
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-10
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protein-protein interaction (PPI) Co-expression protein Lung carcinogenesis
Content Type	Text
Resource Type	Article

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