NDLI: Human microRNAs targeting hepatitis C virus

Content Provider	IEEE Xplore Digital Library
Author	Eid, F.E. Elmarakeby, H. Heath, L. ElHefnawi, M.
Copyright Year	2014
Description	Author affiliation: Dept. of Comput. Sci., Math. & Comput. Sci., Virginia Tech, Blacksburg, VA, USA (Eid, F.E.; Elmarakeby, H.; Heath, L.) \|\| Inf. & Syst. Dept., Nat. Res. Center, Cairo, Egypt (ElHefnawi, M.)
Abstract	microRNA (miRNA) is a post-transcriptional gene regulation mechanism that mediates sequence-specific degradation of the targeted RNA and thus provides an opportunity for the development of oligonucleotide-based drugs. Here, we propose a systematic approach for finding, selecting, and validating miRNAs that target conserved regions in the hepatitis C virus (HCV). Different factors, such as target conservation, target accessibility, miRNA and target RNA thermodynamics, are considered in our pipeline. The conservation profiles of six major genotypes of HCV have been analyzed and the potential conserved regions are selected for downstream analysis based on their entropy and length. An in silico protocol for predicting the miRNA targets in HCV highly conserved regions is devised, and a set of potential miRNAs is filtered and verified using different techniques. Some of the predicted miRNAs were previously experimentally validated, which gives support to our analysis.
Starting Page	184
Ending Page	187
File Size	103574
Page Count	4
File Format	PDF
ISBN	9781479947997
ISSN	21654255
DOI	10.1109/MECBME.2014.6783236
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-02-17
Publisher Place	Qatar
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins RNA Genomics Prediction algorithms Entropy Bioinformatics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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