NDLI: Modulation of mRNA circadian transcription cycle by microRNAs

Content Provider	IEEE Xplore Digital Library
Author	Ptitsyn, A. Ptitsyna, N. Elsebakhi, E. Marincola, F. Al-Ali, R. Temanni, M.-R. AlSaad, R. Wang, E.
Copyright Year	2014
Description	Author affiliation: Sidra Med. & Res. Center, Doha, Qatar (Ptitsyn, A.)
Abstract	MicroRNAs are important modulators of gene expression. There is anecdotal evidence that the abundance of some microRNAs varies in circadian or approximately daily rhythm. In this study, using publicly available data we attempt a systematic analysis of co-expression between microRNAs and their prospective mRNA targets. An advanced analysis of periodicity with the application of digital filters in phase continuum revealed a baseline rhythmic oscillation on over 80% of both mRNA and microRNA populations. This computational observation adds evidence to the theory that microRNAs play an active role in modulation of rhythmic expression as a general rule rather than special exemption. We also explore the immediate implications of inferred oscillatory behavior for modeling of mRNA-miRNA dynamics.
Starting Page	180
Ending Page	183
File Size	338914
Page Count	4
File Format	PDF
ISBN	9781479947997
ISSN	21654255
DOI	10.1109/MECBME.2014.6783235
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-02-17
Publisher Place	Qatar
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Smoothing methods RNA Gene expression Mathematical model Oscillators Clocks Testing
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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