NDLI: Multi objective optimization of drug regimens in cancer chemotherapy using a PK-PD model

Content Provider	IEEE Xplore Digital Library
Author	Batmani, Yazdan Khaloozadeh, Hamid
Copyright Year	2011
Description	Author affiliation: Control Engineering, K.N. Toosi University of Technology, Tehran, Iran (Batmani, Yazdan; Khaloozadeh, Hamid) Mathematical modeling and methods from control theory are employed to optimize drug regimens in cancer chemotherapy. In this paper, we utilized a PK-PD model to describe the effects of drugs on the tumor cells. In chemotherapy, it is essential to prescribe the drug dosages in a way that the number of cancer cells decreases while the least side effects are imposed to the patient. So, the consideration of simultaneous drug effects on both cancer and healthy cells (in this paper white blood cells) in an optimal drug regimen is necessary. Therefore, we have considered two cost functions to minimize the area under curve of tumors as well as the side effects on the patient during chemotherapy. Using these cost functions the drug regimens are calculated with the multi objective optimization (MOO) method. Thereafter, the best drug regimen from the set of these optimal regimens can be appropriately selected by oncologists according to the specific conditions of the patient. Numerical simulations are given to illustrate the flexibility of the proposed method.
Starting Page	1
Ending Page	6
File Size	336317
Page Count	6
File Format	PDF
ISBN	9781457707308
e-ISBN	9789644634284
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-05-17
Publisher Place	Iran
Access Restriction	Subscribed
Rights Holder	AmirKabir Univ of Tech
Subject Keyword	Drugs Pharmacokinetics and pharmacodynamics (PK-PD) model Optimal Drug Regimen Multi Objective Optimization (MOO) Cancer Chemotherapy Cost function Plasmas Mathematical model Cancer Tumors
Content Type	Text
Resource Type	Article

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