NDLI: Calcium leak induced sinus bradycardia

Content Provider	IEEE Xplore Digital Library
Author	Wang, Qingjie Kharche, Sanjay Jones, Gareth Luo, Cunjin Tang, Chengchun Zhang, Henggui
Copyright Year	2015
Description	Author affiliation: School of Computer Science and Technology, Harbin Institute of Technology, China (Luo, Cunjin) \|\| School of Physics and Astronomy, University of Manchester, M13 9PL, UK (Kharche, Sanjay; Jones, Gareth; Zhang, Henggui) \|\| Department of Cardiology, Zhongda Hospital of Southeast University, Nanjing, China (Wang, Qingjie; Tang, Chengchun)
Abstract	Bradycardia is found to be a complication during catecholaminergic polymorphic ventricular tachycardia in which calcium leak plays a pivotal role. In this computational study, we determined the effects of sarcoplasmic reticulum calcium leak on sino-atrial node and ventricular model cells function. A sarcoplasmic reticulum calcium leak current, Jleak, was increased in sino-atrial node and ventricle model cells. The Jleak current is determined by v2, the calcium leak rate constant from the net sarcoplasmic reticulum. In the sino-atrial node cell model, the pacing cycle length increased steadily till v2values became 3.1×10−5 ms−1. Further increase of v2 made pacemaking give rise to long-short, big amplitude-small amplitude oscillations as well as arrest. The amplitude of subspace calcium, calcium diffusion, maximum upstroke velocity of the membrane potential, L-type calcium current and Na+/Ca2+ exchanger current were decreased when v2 was increased in sino-atrial node cell model. However, the effects of Jleak on ventricular action potential and ionic currents are small. The results show the significance of calcium leak as a major mechanism of sino-atrial node dysfunction.
Starting Page	1109
Ending Page	1112
File Size	375121
Page Count	4
File Format	PDF
ISBN	9781509006854
ISSN	2325887X
e-ISBN	9781509006847
DOI	10.1109/CIC.2015.7411109
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-09-06
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Calcium Lead
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

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