NDLI: Left ventricular-aortic coupling in sickle cell disease underlies diastolic dysfunction

Content Provider	IEEE Xplore Digital Library
Author	Bollache, Emilie Kachenoura, Nadjia Lang, Roberto M. Mor-Avi, Victor Patel, Amit R.
Copyright Year	2015
Description	Author affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM UMR_S 1146, CNRS UMR 7371, Laboratoire d'Imagerie Biomédicale, France (Bollache, Emilie; Kachenoura, Nadjia) \|\| Department of Medicine, University of Chicago Medical Center, USA (Lang, Roberto M; Mor-Avi, Victor; Patel, Amit R)
Abstract	Left ventricular (LV) diastolic dysfunction (DD) is associated with increased mortality in sickle cell disease (SCD) but its mechanisms are not well known, preventing the development of effective therapies. Our hypothesis was that DD in SCD may be due to changes in aortic properties. We studied 31 SCD patients (32±7yrs) and 12 normal controls (29±10yrs) who underwent echocardiography and MRI on the same day. LV diastolic function was assessed from echocardiography. MRI included velocity-encoded images of the aorta to measure ascending aortic cross-sectional area, stroke volume, distensibility, as well as volumes of the forward (FFV) and backward (BFV) blood flow. Compared to controls, SCD patients had increased aortic area, stroke volume, and both FFV and BFV, while distensibility was similar. DD was found in 5/31 patients (16%), in whom the increase in BFV and BFV/FFV ratio was even more pronounced, when compared to the remaining patients. Our findings suggest a potential mechanism of DD in SCD patients. Increased cardiac output induced by chronic anemia might be associated with aortic dilation, which may increase LV afterload (BFV), ultimately leading to LV DD. If confirmed in larger studies, these aortic changes could be targets for specific therapies as a way to prevent the development of DD in SCD.
Starting Page	713
Ending Page	716
File Size	399670
Page Count	4
File Format	PDF
ISBN	9781509006854
ISSN	2325887X
e-ISBN	9781509006847
DOI	10.1109/CIC.2015.7411010
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-09-06
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Magnetic resonance imaging Medical treatment Lead Heart rate Focusing Area measurement Size measurement
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Abnormalities in aortic properties: a potential link between left ventricular diastolic function and ventricular—aortic coupling in sickle cell disease

Prevalence of left ventricular diastolic dysfunction by cardiac magnetic resonance imaging in thalassemia major patients with normal left ventricular systolic function

Association of Left Atrial Myocardial Function With Left Ventricular Diastolic Dysfunction in Subjects With Preserved Systolic Function: A Strain Rate Imaging Study

Early detection of left ventricular diastolic dysfunction in Chagas' disease

Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction

Magnetic Resonance Imaging With 3-Dimensional Analysis of Left Ventricular Remodeling in Isolated Mitral Regurgitation

Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure.

Left ventricular hypertrophy, diastolic dysfunction and right ventricular load predict outcome in moderate aortic stenosis

Cross-Sectional Relationships of Proximal Aortic Stiffness and Left Ventricular Diastolic Function in Adults in the Community.

Left ventricular-aortic coupling in sickle cell disease underlies diastolic dysfunction

Similar Documents

Abnormalities in aortic properties: a potential link between left ventricular diastolic function and ventricular—aortic coupling in sickle cell disease

Prevalence of left ventricular diastolic dysfunction by cardiac magnetic resonance imaging in thalassemia major patients with normal left ventricular systolic function

Association of Left Atrial Myocardial Function With Left Ventricular Diastolic Dysfunction in Subjects With Preserved Systolic Function: A Strain Rate Imaging Study

Early detection of left ventricular diastolic dysfunction in Chagas' disease

Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction

Magnetic Resonance Imaging With 3-Dimensional Analysis of Left Ventricular Remodeling in Isolated Mitral Regurgitation

Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure.

Left ventricular hypertrophy, diastolic dysfunction and right ventricular load predict outcome in moderate aortic stenosis

Cross-Sectional Relationships of Proximal Aortic Stiffness and Left Ventricular Diastolic Function in Adults in the Community.

Left ventricular-aortic coupling in sickle cell disease underlies diastolic dysfunction