NDLI: Automatic assessment of right ventricular repolarisation dispersion during diagnostic ajmaline test for suspected Brugada syndrome

Content Provider	IEEE Xplore Digital Library
Author	Batchvarov, V.N. Christov, I.I. Bortolan, G. Govindan, M. Camm, A.J. Behr, E.R.
Copyright Year	2009
Description	Author affiliation: St George's University of London, UK (Batchvarov, V.N.; Govindan, M.; Camm, A.J.; Behr, E.R.) \|\| Centre of Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria (Christov, I.I.) \|\| Institute of Biomedical Engineering ISIB - CNR, Padova, Italy (Bortolan, G.)
Abstract	We used principal components analysis (PCA) to quantify right ventricular (RV) repolarisation dispersion during diagnostic ajmaline test for suspected Brugada syndrome (BS). 10-second 15-lead electrocardiograms (ECG) (500 Hz, 12 standard leads + V1 to V3 from $3^{rd}$ intercostal space, V1h to V3h) were acquired in 61 patients (pts) with suspected BS (38 men, age 39±17 years) during ajmaline administration. PCA (ratio $2^{nd}/1^{st}$ eigenvalue) was performed on the J-Tend interval using a) leads V1 to V3 (PCAstand), b) V1h to V3h (PCAhigh) and c) V1 to V3 + V1h to V3h (PCAtotal). Pts with positive tests (n=20) had significantly higher PCAhigh and PCAtotal, on pre-test ECGs than those with negative tests. The maximum drug-induced increase of PCA was significantly greater in pts with positive than in those with negative tests (e.g. PCAhigh 6406±12622% vs 192±350%, p=0.004). Assessment of RV repolarisation dispersion using PCA can help the diagnosis of BS.
Starting Page	297
Ending Page	300
File Size	172396
Page Count	4
File Format	PDF
ISBN	9781424472819
ISSN	02766547
e-ISBN	9781424472826
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-09-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Computers in Cardiology(CinC)
Subject Keyword	Automatic testing Electrocardiography Principal component analysis Biomedical engineering Drugs Medical tests System testing Erbium Delay Fibrillation
Content Type	Text
Resource Type	Article

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