NDLI: Prognostic value of intra-QRS and ST-T micro-variability

Content Provider	IEEE Xplore Digital Library
Author	Kestler, H.A. Hoher, M.
Copyright Year	2003
Description	Author affiliation: Neural Inf. Process., Ulm Univ., Germany (Kestler, H.A.)
Abstract	Previously, we found that patients with malignant ventricular arrhythmias show an increased beat-to-beat micro-variability of de- and repolarization, indicated by an increased variability of QRS duration and an increased intra-QRS (QVI)and ST-T (TVl) variability compared to healthy subjects. In this study we investigated the prognostic value of the previously found markers QVI and TVI of beat-to-beat variability in terms of mortality. Patient (960) assignment had to be to one of the following subgroups: (a) no organic heart disease, (b) coronary artery disease, or (c) spontaneous or inducible ventricular tachycardia or ventricular fibrillation. High-resolution ECGs were recorded. Beat-to-beat micro-variability measurement was based on 200 consecutive sinus beats per individual. Total and cardiac mortality was highest in the group with malignant arrhythmias (13.3% and 12%). The Cox proportional hazards regression model on the singular factors of QVl and TVl revealed a connection to survival. This was valid for both the 1-year (QVl p = 0.006, TVl p = 0.009) and 2-year (QVI p = 0.015, TVI p = 0.008) follow-up. We conclude that increased QRS- and T-variability indicating increased anisotropy of de- and repolarisation is associated with an increased mortality.
Sponsorship	European Soc. of Cardiology Nat. Inst. of Health, USA
Starting Page	89
Ending Page	92
File Size	276225
Page Count	4
File Format	PDF
ISBN	078038170X
ISSN	02766547
DOI	10.1109/CIC.2003.1291097
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-21
Publisher Place	Greece
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cardiac disease Electrocardiography TV interference Cardiology Cancer Coronary arteriosclerosis Fibrillation Cardiovascular diseases Parkinson's disease Hospitals
Content Type	Text
Resource Type	Article

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