NDLI: Contrast echocardiographic digital analysis using HDI Lab

Content Provider	IEEE Xplore Digital Library
Author	Cardon, L.A. Odabashian, J.A. Jaber, W.A. Prior, D.L. Vaughn, S.E. Thomas, J.D.
Copyright Year	1998
Description	Author affiliation: Cardiovascular Imaging Center, Cleveland Clinic Found., OH, USA (Cardon, L.A.)
Abstract	Echocardiographic image interpretation is predominantly a subjective process, generally performed using the 'eyeball' technique and thus critically dependent on the reviewer's experience. In the past, software packages for digital image analysis have been limited. Recently, Advanced Technology Laboratories (ATL) has introduced HDI Lab for the analysis of digital images from the ATL HDI 5000 CV ultrasound machine. The purpose of this study was to apply HDI Lab to characterize the normal patterns of echocardiographic contrast uptake into the myocardium. Only by understanding the spatial variation in contrast uptake with normal perfusion can this technique be applied to patients with coronary artery disease. Digital images were obtained from 7 normal volunteers pre and post injection of Optison, microbubbles of albumin containing perfluorocarbon gas. Apical 4 and 2 chamber images were obtained in pulse-inversion harmonic mode, gated to end-diastole of every fourth beat, and stored to either a 3.5" magneto-optical disk (MOD) on the echo machine or to a remote PC via a network connection. Images were stored in a polar format containing data from individual scan lines and echo density quantified from regions of interest in the basal, mid and apical regions of the inferior, septal, anterior and lateral walls. Multifactorial analysis of variance demonstrated highly significant (p<0.001) increase in echogenicity of all walls indicating definite contrast presence in the myocardium. However, there was considerable variability in contrast effect with a strong (p<0.004) gradient from the base (least intense) to the apex (most intense), perhaps due to attenuation from overlying structures. Such heterogeneity of effect will have to be considered as contrast echocardiography is applied to patients with coronary artery disease.
Starting Page	449
Ending Page	452
File Size	557012
Page Count	4
File Format	PDF
ISBN	0780352009
ISSN	02766547
DOI	10.1109/CIC.1998.731899
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-09-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Digital images Image analysis Myocardium Coronary arteriosclerosis Software packages Laboratories Ultrasonic imaging Magnetooptic effects Analysis of variance Attenuation
Content Type	Text
Resource Type	Article

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