NDLI: Fibrillation in a two-dimensional sheet of atrial myocardium: a computational study of wavefront-obstacle interactions

Content Provider	IEEE Xplore Digital Library
Author	Azene, E.M. Trayanova, N.A. Warmen, E.
Copyright Year	1998
Description	Author affiliation: Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA (Azene, E.M.)
Abstract	The goal of this simulation study is to examine the interaction of waves of fibrillation with centrally-located obstacles in a two-dimensional sheet of myocardium, thus providing information about the spatial organization of the wavefronts following obstacle creation. The authors used a monodomain model with modified Luo-Rudy I membrane kinetics to model the atrial myocardium. They considered three types of obstacles of equal area: a passive tissue obstacle, a conductive obstacle, and a non-conductive obstacle. For the obstacle dimensions tested, the authors found that interaction of only the passive obstacle with fibrillatory waves resulted in termination of fibrillation. They suggest that current returned to the active tissue from the conductive obstacle's interior promotes wave fragmentation and continued fibrillation. Similarly, they believe current reflected by the non-conductive obstacle also helps sustain fibrillation.
Starting Page	185
Ending Page	188
File Size	569681
Page Count	4
File Format	PDF
ISBN	0780352009
ISSN	02766547
DOI	10.1109/CIC.1998.731763
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-09-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Lesions Biomedical computing Kinetic theory Atrial fibrillation Biomedical engineering Computational modeling Testing Rhythm Heart
Content Type	Text
Resource Type	Article

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