NDLI: TEST: a Web-based T-cell epitope search tool

Content Provider	IEEE Xplore Digital Library
Author	Yingdong Zhao Grover, L. Simon, R.
Copyright Year	2001
Description	Author affiliation: Nat. Cancer Inst., Rockville, MD, USA (Yingdong Zhao)
Abstract	Presents the World Wide Web-based tool TEST (T-cell Epitope Search Tool) for searching T-cell epitopes based on experimental data from positional scanning synthesized combinatorial libraries (PS-SCL). Implemented with a strong statistical analysis package, a relational database and Java applets, the TEST tool first generates a scoring matrix and then uses the matrix to scan and score all possible peptides in the user-specified protein database. Laboratory information management, such as data storage, data retrieval and data comparison, is also provided. The TEST tool has been applied to a variety of T-cell clones having known or unknown specificities with reliable predictions. The system should prove useful for the identification of target antigens in infectious diseases, autoimmune disorders and tumors, and also for the development of vaccines.
Sponsorship	IEEE Comput. Soc. Tech. Committee on Computational Med.
Starting Page	493
Ending Page	497
File Size	281053
Page Count	5
File Format	PDF
ISBN	0769510043
ISSN	10637125
DOI	10.1109/CBMS.2001.941767
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-07-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Testing Relational databases Libraries Statistical analysis Packaging Java Peptides Proteins Laboratories Information management
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Computer Science Applications

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