NDLI: Control of abnormal electrical cavity with applied electrical fields

Content Provider	IEEE Xplore Digital Library
Author	Durand, D. Kayyali, H. Warman, E.
Copyright Year	1992
Description	Author affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA (Durand, D.; Kayyali, H.; Warman, E.)
Abstract	Electrical fields applied to the cerebellum and the hippocampus have been shown to modulate the excitability of neurons provided that the electrical field is properly oriented with the dendritic structure. The effect of electrical fields has been tested on epileptiform electrical activity in order to determine the feasibility of blocking or reducing this type of abnormal neuronal firing. The experiments were done using the hippocampal slice in-vitro preparation, since it allows direct visual control of the position of the electrodes in order to align the electrical field with the dendrites. Epileptiform electrical activity was generated by adding 3500 units/ml of penicillin to the artificial cerebrospinal fluid solution. Low-intensity electrical fields were then applied with a monopolar or a tripolar electrode using constant current pulses. It is shown that it is possible to achieve a reduction in the amplitude of the electrical activity greater than 80%. Preliminary results have confirmed that neuronal firing is decreased by the applied fields.<>
Starting Page	942
Ending Page	943
File Size	219962
Page Count	2
File Format	PDF
ISBN	0780307852
DOI	10.1109/IEMBS.1988.95269
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1988-11-04
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Epilepsy Extracellular Neurons Testing Biomedical engineering Hippocampus Design methodology Surgery Prosthetics
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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