NDLI: NMR spectroscopy in tumors

Content Provider	IEEE Xplore Digital Library
Author	Podo, F. Carpinelli, G. Proietti, E. Belardelli, F.
Copyright Year	1992
Description	Author affiliation: Lab. of Cell Biol., Istituto Superiore di Sanita, Rome, Italy (Podo, F.; Carpinelli, G.; Proietti, E.; Belardelli, F.)
Abstract	Alterations in the levels of phospholipid metabolites and variations of intracellular pH may represent early biochemical responses of cells to altered conditions of proliferation in vitro and in vivo. These metabolic alterations can be studied by /sup 31/P NMR (nuclear magnetic resonance) in intact tissues, by respectively analyzing the resonances contributing the phosphorylmonoester and phosphoryldiester spectral profiles and monitoring the chemical shift of inorganic phosphate signal. A review is presented of studies carried out in the last five years to assess the value of these spectral variations for monitoring early responses of experimental tumors to the antitumor activity of two biological response modifiers, namely murine interferon alpha / beta and recombinant tumor necrosis factor.<>
Starting Page	322
Ending Page	323
File Size	174463
Page Count	2
File Format	PDF
ISBN	0780307852
DOI	10.1109/IEMBS.1988.94539
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1988-11-04
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nuclear magnetic resonance Spectroscopy Neoplasms Chemical analysis In vitro In vivo Signal analysis Magnetic analysis Inorganic chemicals Monitoring
Content Type	Text
Resource Type	Article

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