NDLI: A mechanical model to simulate uptake and elimination of inhalation anesthetics

Content Provider	IEEE Xplore Digital Library
Author	Loughlin, P.J. Bowes, W.A. Westenskow, D.R.
Copyright Year	1992
Description	Author affiliation: Dept. of Anesthesiology, Utah Univ., Salt Lake City, UT, USA (Loughlin, P.J.; Bowes, W.A.; Westenskow, D.R.)
Abstract	Using olive oil to simulate body tissues, a mechanical model of uptake and elimination of inhalation anesthetics was developed. Body tissues were grouped according to anesthetic solubility and blood perfusion, and modeled with equivalent oil volumes. Changes in cardiac output were simulated by varying gas flows through the oil chambers. Alveolar ventilation was augmented by adjusting the minute ventilation setting of the ventilator. During 64 minutes of uptake and washout, the mechanical model end-tidal halothane concentration remained within 0.07 vol.% of a computer simulation. The model may prove useful in developing and testing anesthesia equipment without the need for animal experiments or human volunteers.<>
Starting Page	589
Ending Page	590
File Size	198150
Page Count	2
File Format	PDF
ISBN	0780307852
DOI	10.1109/IEMBS.1988.94735
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1988-11-04
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Anesthetic drugs Petroleum Ventilation Blood Computational modeling Fluid flow Computer simulation Testing Anesthesia Animals
Content Type	Text
Resource Type	Article

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A mechanical model to simulate uptake and elimination of inhalation anesthetics