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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Li, X. Han, E.T. Newitt, D. Majumdar, S. |
| Copyright Year | 2004 |
| Description | Author affiliation: Dept. of Radiol., California Univ., San Francisco, CA, USA (Li, X.) |
| Abstract | Osteoarthritis (OA) is a disease of articular cartilage degeneration. Early detection of changes in cartilage would be essential for preventing the progression of disease and for monitoring therapy in OA. The T/sub 1/spl rho// relaxation parameter describes the spin-lattice relaxation in the rotating frame and has been considered as a promising tool to detect the loss of proteoglycan (PG), which is an early precursor of OA. The goal of this study was to develop a T/sub 1/spl rho//-weighted imaging method based on spiral imaging and to examine the feasibility of applying it to in vivo cartilage imaging. T/sub 1/spl rho//-weighted imaging with a pre-encoded spin-lock pulse cluster followed by a spiral acquisition sequence was implemented on GE 1.5 T scanners. tip maps were generated by a pixel-by-pixel fit of the T/sub 1/spl rho//-weighted data to an exponential decay. Homogeneous agarose phantoms and the patella cartilage of one healthy volunteer were imaged using the developed techniques. T/sub 1/spl rho// in agarose phantoms decreased as agarose concentration increased. No significant tip dispersion was seen within spin-lock frequencies ranging from 150 Hz to 1000 Hz in agarose phantoms. T/sub 1/spl rho//-weighted images of the healthy volunteer showed good contrast between cartilage and surrounding tissues. The fitted T/sub 1/spl rho// value of patella cartilage was within the range of 30-100 ms. |
| Starting Page | 1032 |
| Ending Page | 1035 |
| File Size | 1060193 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780384393 |
| DOI | 10.1109/IEMBS.2004.1403339 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2004-09-01 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Spirals Imaging phantoms Bone diseases Degenerative diseases Osteoarthritis Condition monitoring Medical treatment In vivo Pulse generation Pixel T Cartilage imaging Magnetic Resonance Imaging Spin-lock Spiral imaging |
| Content Type | Text |
| Resource Type | Article |
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