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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | den Buijs, J. Juloski, A.L. Ivanics, T. Ligeti, L. van der Vusse, G.J. van Riel, N.A.W. |
| Copyright Year | 2004 |
| Description | Author affiliation: Dept. of Electr. Eng., Eindhoven Univ. of Technol., Netherlands (den Buijs, J.; Juloski, A.L.) |
| Abstract | So far, the processes involved in regulation of intracellular calcium (Ca/sub i//sup 2+/) in cardiomyocytes have been mainly studied through biochemical and isolated cell analysis. Here, we present a novel technique to model and identify cardiac Ca/sub i//sup 2+/-cycling under physiologically relevant conditions in the intact beating heart. Ca/sub i//sup 2+/ was measured using fluorescence techniques in ex vivo perfused rat hearts. For analysis, we developed a parametric mathematical model, switching between active and inactive calcium release. The kinetic parameters of the two submodes of the model were computed using a recently developed technique from hybrid system identification. Application of the method to control and isoproterenol-stimulated hearts resulted in parameter values within a physiologically reliable range. |
| Starting Page | 841 |
| Ending Page | 844 |
| File Size | 206085 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780384393 |
| DOI | 10.1109/IEMBS.2004.1403289 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2004-09-01 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Calcium Heart Strontium Biomembranes Steady-state Kinetic theory Proteins Rats Mercury (metals) Performance evaluation Perfused Heart Hybrid systems Identification Mathematical model |
| Content Type | Text |
| Resource Type | Article |
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