NDLI: In vitro and in vivo measurement for biological applications using micromachined probe

Content Provider	IEEE Xplore Digital Library
Author	Jung-Mu Kim Donghoon Oh Jeonghoon Yoon Sungjoon Cho Namgon Kim Jeiwon Cho Youngwoo Kwon Changyul Cheon Yong-Kweon Kim
Copyright Year	1963
Abstract	We developed a small-sized micromachined probe for the measurement of biological properties using microelectromechanical systems (MEMS) technology. We also experimentally showed the suitability of the micromachined probe for biological applications through in vivo, as well as in vitro measurements of various types of tissue. We measured the permittivities of 0.9% saline and the muscle and fat of pork using the micromachined probe after liquid calibration. The measured permittivities of 0.9% saline and pork agreed well with both the expected values of the Cole-Cole equation along with the measured values obtained through the use of a 1-mm-diameter open-ended coaxial probe. We also performed in vivo measurements of breast cancer tissue implanted in an athymic nude mouse to show the suitability of the small-sized micromachined probe for practical biological applications. Through the obtained data, the capability of the micromachined probe of distinguishing different tissue types from one another was shown. The actual aperture size of the micromachined probe is only 240 /spl mu/m /spl times/ 70 /spl mu/m and, therefore, we can extract the biological information from very small biological tissues and drastically decrease the invasiveness of this method through the implementation of the small probe created through the use of MEMS technology.
Sponsorship	IEEE Microwave Theory and Techniques Society
Starting Page	3415
Ending Page	3421
Page Count	7
File Size	1458764
File Format	PDF
ISSN	00189480
Volume Number	53
Issue Number	11
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-11-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vitro In vivo Probes Permittivity measurement Biological tissues Micromechanical devices Microelectromechanical systems Muscles Calibration Equations permittivity measurement in vivo microelectromechanical systems (MEMS) micromachined probe
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Electrical and Electronic Engineering Radiation

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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