NDLI: A controller for regulation of mean arterial blood pressure using optimum nitroprusside infusion rate

Content Provider	IEEE Xplore Digital Library
Author	Behbehani, K. Cross, R.R.
Copyright Year	1964
Abstract	An integrating self-tuning control strategy for control of mean arterial blood pressure using sodium nitroprusside is presented. Next to robust performance, the most attractive feature of the controller is its capability to optimize the quantity of infused medication without introducing a bias in the blood pressure level, a problem that exists in some of the other adaptive control strategies that have been proposed previously. Further, the controller design requires only the knowledge of the pure delay and the order of the transfer function describing the patient's response to the medication; it does not require that the entire transfer function be specified. The derivation of the controller is not based on the patient response to sodium nitroprusside; indeed, it is a general adaptive control strategy for control of systems with transport delay. The controller performs robustly in the presence of variations in the patient response and successfully controls the pressure at the desired level. The ability of this strategy to reduce the amount of infused medication makes it potentially attractive for use in clinical applications, as large doses or long-term use of sodium nitroprusside can adversely affect central nervous system and hematopoietic tissues.<>
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	9
File Size	691222
Starting Page	513
Ending Page	521
File Format	PDF
ISSN	00189294
Volume Number	38
Issue Number	6
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1991-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pressure control Arterial blood pressure Medical control systems Robust control Adaptive control Transfer functions Control systems Blood pressure Delay systems Central nervous system
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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