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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Bailey, J.M. Shafer, S.L. |
| Copyright Year | 1964 |
| Abstract | The disposition of many drugs following an intravenous bolus injection can be described by a biexponential or triexponential equation. Computer-controlled infusion pumps have been developed which dose intravenous drugs based on models of drug disposition. These pumps can maintain steady plasma drug concentrations and facilitate controlled increases and decreases in drug concentration, enhancing titration of intravenous drugs. Several investigators have proposed analytical solutions to the biexponential and triexponential disposition functions for use in computer-controlled infusion pumps. Because of the complexity of these analytical solutions, other investigators have used numerical techniques to approximate the analytical solution. The authors have derived an extremely simple analytical solution to polyexponential disposition functions. This solution simplifies both the prediction of the plasma drug concentration by a computer-controlled infusion pump and the stepwise calculation of the infusion rate required to maintain constant plasma drug concentrations.< |
| Sponsorship | IEEE Engineering in Medicine and Biology Society |
| Page Count | 4 |
| File Size | 287572 |
| Starting Page | 522 |
| Ending Page | 525 |
| File Format | |
| ISSN | 00189294 |
| Volume Number | 38 |
| Issue Number | 6 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 1991-06-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Drugs Plasma stability Plasma applications Differential equations Helium Committee on Communications and Information Policy Difference equations |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering |
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