NDLI: A VLSI Circuit Emulation of Chemical Synaptic Transmission Dynamics and Postsynaptic DNA Transcription

Content Provider	IEEE Xplore Digital Library
Author	Alam, S. Rezaul Hasan, S.M.
Copyright Year	1993
Abstract	Chemical synaptic transmission dynamics in the mammalian wetware control the activities of a living creature. During this cascading process, biological information is transferred from one neuron to another (the next) neuron. Many electronic circuits have been designed to implement neural synaptic communication; however, the invention of the memristor has raised the prospect of novel, highly efficient, and miniaturized neural circuit emulation. A novel VLSI circuit emulation of the chemical synaptic process at the biomolecular level (molecular level neuromorphic circuit) has been presented in this paper. Memristors and operational amplifiers in various configurations are key components in this silicon-based emulation. Commencement of deoxyribonucleic acid (DNA) transcription of certain neural gene in the postsynaptic neuron (through Ca⁺² ion stimulation) is a major consequence of the synaptic transmission dynamics. Thus, this paper also proposes an integrated circuit model for the postsynaptic neural DNA transcription. A comparison of the silicon-based measured results using the proposed model with experimentally reported biological data justifies the validity of the proposed model. Stochastic aspects are also simulated through Monte Carlo analysis of the circuit model.
Sponsorship	IEEE Computer Society Association for Computing Machinery (ACM)/SIGDA IEEE Computer Society Technical Committee on Design Automation
Starting Page	678
Ending Page	691
Page Count	14
File Size	3438027
File Format	PDF
ISSN	10638210
Volume Number	24
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2016-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neurotransmitters Neurons Integrated circuit modeling Calcium Chemicals Electric potential DNA VLSI emulation. Action potential deoxyribonucleic acid (DNA) gene transcription neuromorphic circuits neurotransmitter synapse synaptic transmission dynamics VLSI emulation
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Software Hardware and Architecture

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