NDLI: A Wireless IC for Time-Share Chemical and Electrical Neural Recording

Content Provider	IEEE Xplore Digital Library
Author	Roham, M. Covey, D.P. Daberkow, D.P. Ramsson, E.S. Howard, C.D. Heidenreich, B.A. Garris, P.A. Mohseni, P.
Copyright Year	1966
Abstract	A 1.1-mW 4-channel integrated circuit for wireless time-share monitoring of chemical and electrical neural activity in the brain is described. The chip architecture can be configured to perform neurochemical monitoring using 300-V/s fast-scan cyclic voltammetry (FSCV) and neuroelectrical recording using extracellular electrophysiology. The 5-mm² IC is fabricated in AMI 0.5 ¿m double-poly triple-metal n-well CMOS process and uses a 76-¿W, third-order, continuous-time, ¿¿ modulator (CT-¿¿M) per channel that achieves an input-referred noise of 56.7 pA_rms (dc-5 kHz) and 3.5 ¿V_rms (1.1-5 kHz) for chemical and electrical neuromonitoring, respectively. The chip architecture also incorporates monolithic circuitry for generating FSCV and biphasic constant-current stimulus waveforms. The chip has been externally interfaced with carbon-fiber microelectrodes (CFMs) implanted acutely in the caudate-putamen of an anesthetized rat, and enables chemically resolved monitoring of electrically evoked dopamine release and its postsynaptic bioelectrical response at the same recording site. The dopamine limit of detection (LOD) corresponding to a signal-to-rms noise ratio of three is estimated to be 16.7 nM based on the measured noise performance of the device and its sensitivity to dopamine determined empirically via flow injection analysis. This detection limit compares favorably with the amplitude of phasic dopamine transients that varies in the range of 40 nM-1 ¿M.
Sponsorship	IEEE Solid-State Circuits Society IEEE Electron Devices Society IEEE Circuits and Systems Society Japan Society of Applied Physics (JSAP) IEEE Microwave Theory and Techniques Society IEEE San Francisco Section Bay Area Council Univ. PA IEEE
Starting Page	3645
Ending Page	3658
Page Count	14
File Size	1859334
File Format	PDF
ISSN	00189200
Volume Number	44
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-12-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Monitoring Power capacitors Integrated circuit noise Signal to noise ratio Extracellular CMOS integrated circuits Ambient intelligence CMOS process Chemical processes Microelectrodes wireless integrated circuit Delta-sigma modulator dopamine fast-scan cyclic voltammetry neurochemical monitoring neuroelectrical recording
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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