NDLI: Physical Factors Affecting Quantitative Measurements Using Camera-Based Single Photon Emission Computed Tomography (Spect)

Content Provider	IEEE Xplore Digital Library
Author	Jaszczak, Ronald J. Coleman, R. Edward Whitehead, Frank R.
Copyright Year	1963
Abstract	The qualitative imaging capability of single photon emission computed tomography (SPECT) using complete angular sampling has previously been demonstrated by several investigators. In order to obtain quantitative information such as absolute volumes and regional radionuclide concentrations using SPECT systems it is necessary to determine the system characteristics which contribute to the intrinsic measurement process and limit its precision. This manuscript describes some of the more important physical factors which can affect the measurement process of scintillation camera based SPECT systems and provides information concerning the type of quantitative measurements that can currently be obtained with these devices. Using our rotating camera based SPECT system the root mean square (rms) noise level in attenuation corrected images of a uniform cylindrical source was measured and found to agree with theoretically predicted vaiues obtained with the following equation: %rms = 100 (1.8)3/2 ¿ Reff Rs1/2 Abody Cavg / 21/2Ntotal1/2(FF)1/2 where Reff is the "effective" radius of the source, RS is the actual source radius, Abody is the attenuation factor for surrounding non-source body material, Cavg is the average attenuation correction factor for the center of the source, Ntotal is the total number of events, and FF is the algorithm filter factor and equals the integral of the square of the spatial frequency filter function. Using a semi-automatic region of interest (ROI) program and the multi-slice capability of our SPECT system, the volumes of plastic spherical sources placed inside a larger cylindrical source were measured.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	69
Ending Page	80
Page Count	12
File Size	4639555
File Format	PDF
ISSN	00189499
Volume Number	28
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1981-02-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Single photon emission computed tomography Volume measurement Current measurement Cameras Filters Sampling methods Root mean square Noise level Attenuation measurement Frequency measurement
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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