NDLI: Development of Magnetic Particle-Based Immunoassays and Their Applications in Diabetes Monitoring

Content Provider	IEEE Xplore Digital Library
Author	Cheng-Tai Chen Chien-An Chen Yu-Yin Tsai Yi-Yen Yuan Yi-Chau Huang Ting-Shou Chen Tsai, J.S.C.
Copyright Year	1965
Abstract	In addition to blood glucose testing, monitoring of blood glycated proteins got considerable attention on the glycemic control of diabetes. Glycated albumin has been reported as a good complementary to or better indicator than glycated hemoglobin for the evaluation of short-term glycemic control. Herein, the development of magnetic particle-based immunoassays for blood glycated proteins is demonstrated. Spherical magnetic particles are fabricated composed of a polystyrene core covered with a thin layer of Fe₃O₄ and SiO₂. The core-shell structure allow us to control a wide size range by using the polystyrene cores of different size, and the silica outer layer can be functionalized easily with silane coupling agents. Aminophenylboronic acid is covalently immobilized onto magnetic particles for the affinity isolation of glycated proteins, while horseradish peroxidase labeled antibodies are used for detection. The assays are optimized and applied successfully to the determination of glycated albumin in standard and human serum samples and show good potential as tools for diabetes monitoring.
Sponsorship	IEEE Magnetics Society
Starting Page	1
Ending Page	4
Page Count	4
File Size	1078498
File Format	PDF
ISSN	00189464
Volume Number	50
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic particles Immune system Diabetes Magnetic separation Magnetic resonance imaging Iron Monitoring magnetic particles glycated albumin immunoassay
Content Type	Text
Resource Type	Article
Subject	Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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