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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Takamura, T. Ko, P.J. Ishikawa, R. Sandhu, A. |
| Copyright Year | 1965 |
| Abstract | Research on medical diagnostics for point of care treatment (POCT) is driven by demand for rapid, high sensitivity, and inexpensive point of care diagnosis of heart disease, infection, allergies and cancer. Demands to improve quantification and affinity necessitate magnetic labels with sizes comparable to target molecules. However, it is extremely challenging to detect small concentrations of sub-200 nm functionalized magnetic labels using magnetoresistive-based sensors. In order to overcome these limitations we have developed a simple procedure for detecting ~ 130 nm sized magnetic labels via magnetically induced capture of micrometer sized superparamagnetic beads by several 130 nm-diameter target beads immobilized on substrates. Here we demonstrate a new method to improve the quantification of our protocol that exploits magnetically induced frictional forces between micro-sized beads and target magnetic labels. By reducing the external magnetic field, the magnetically captured micro-sized beads restart to flow due to electrostatic forces and the strength of the critical external magnetic field for release depends on the number of nano-sized beads immobilized on substrate. Our protocol has the possibility for quantitative biomaterial detection. |
| Sponsorship | IEEE Magnetics Society |
| Starting Page | 2835 |
| Ending Page | 2837 |
| Page Count | 3 |
| File Size | 360812 |
| File Format | |
| ISSN | 00189464 |
| Volume Number | 48 |
| Issue Number | 11 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-11-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Substrates Magnetic resonance imaging Magnetometers Protocols Biosensors Force Electrodes self-assembly Biomedical transducers magnetic labeling magnetoresistive devices medical diagnosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering |
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