NDLI: Hollow fiber clinostat for simulating microgravity in cell culture

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Hollow fiber clinostat for simulating microgravity in cell culture

Content Provider	NASA Technical Reports Server (NTRS)
Copyright Year	1992
Description	A clinostat for simulating microgravity on cell systems carried in a fiber fixedly mounted in a rotatable culture vessel is disclosed. The clinostat is rotated horizontally along its longitudinal axis to simulate microgravity or vertically as a control response. Cells are injected into the fiber and the ends of the fiber are sealed and secured to spaced end pieces of a fiber holder assembly which consists of the end pieces, a hollow fiber, a culture vessel, and a tension spring with three alignment pins. The tension spring is positioned around the culture vessel with its ends abutting the end pieces for alignment of the spring. After the fiber is secured, the spring is decompressed to maintain tension on the fiber while it is being rotated. This assures that the fiber remains aligned along the axis of rotation. The fiber assembly is placed in the culture vessel and culture medium is added. The culture vessel is then inserted into the rotatable portion of the clinostat and subjected to rotate at selected rpms. The internal diameter of the hollow fiber determines the distance the cells are from the axis of rotation.
File Size	525981
Page Count	6
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19920022546
Archival Resource Key	ark:/13960/t2m66dx48
Language	English
Publisher Date	1992-04-14
Access Restriction	Open
Subject Keyword	Biological Effects Cells Biology Gravitational Effects Space Commercialization Springs Elastic Culture Techniques Weightlessness Simulation Microgravity Rotation Indicating Instruments Fibers Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Patent

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