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Experiment k-6-20. the effect of spaceflight on pituitary oxytocin and vasopressin content of rats
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Krasnov, I. Keil, L. Evans, J. Grindeland, R. |
| Copyright Year | 1990 |
| Description | Pituitary levels of oxytocin (OT) and vasopressin (AVP) were measured in rats exposed to 12.5 days of spaceflight (FLT) as well as ground-based controls, one group synchronously maintained in flight-type cages with similar feeding schedules (SYN), and one group in vivarium cages (VIV). Flight rats had significantly less (p less than 0.05) pituitary OT and AVP(1.10 plus or minus 0.04 and 1.69 plus or minus 0.07 micron g, n=5) than either the SYN(1.60 plus or minus 0.08 and 2.11 plus or minus 0.04 micron g, n=5) or VIV (1.54 plus or minus 0.03 and 2.10 plus or minus 0.09 micron g, n=5) control groups, respectively. Because the FLT group mean body weight was significantly less (p less than 0.05) than either control group, the pituitary hormone content was also calculated on the basis of posterior pituitary protein content. When calculated in this manner, pituitary OT in the FLT rats (5.09 plus or minus 0.15 micron g/mg protein) was significantly less (p less than 0.05) than SYN(7.66 plus or minus 0.39 micron g/mg protein) or VIV controls (8.11 plus or minus 0.64 micron g/mg protein). Pituitary AVP was also less in the FLT animals (7.80 plus or minus 0.13 micron g/mg protein) compared to either SYN(9.84 plus or minus 0.51, p less than 0.05) or VIV controls (11.01 plus or minus 0.76, p less than 0.05). The reduced levels of pituitary OT and AVP may have resulted from increased hormone secretion resulting from the combined effects of water deprivation and the stress of the novel microgravity environment. |
| File Size | 392123 |
| Page Count | 6 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19900017157 |
| Archival Resource Key | ark:/13960/t0rr6rd7b |
| Language | English |
| Publisher Date | 1990-02-01 |
| Access Restriction | Open |
| Subject Keyword | Schedules Gravitational Physiology Body Weight Rats Space Flight Water Deprivation Hormones Secretions Proteins Gravitational Effects Pituitary Gland Microgravity Antidiuretics Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
