NDLI: Effects of spaceflight on the proliferation of jejunal mucosal cells

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Effects of spaceflight on the proliferation of jejunal mucosal cells

Content Provider	NASA Technical Reports Server (NTRS)
Author	Sawyer, Heywood R. Phillips, Robert W. Smirnov, K. L. Moeller, C. L.
Copyright Year	1991
Description	The purpose of this project was to test the hypothesis that the generalized, whole body decrease in synthetic activity due to microgravity conditions encountered during spaceflight would be demonstrable in cells and tissues characterized by a rapid rate of turnover. Jejunal mucosal cells were chosen as a model since these cells are among the most rapidly proliferating in the body. Accordingly, the percentage of mitotic cells present in the crypts of Lieberkuhn in each of 5 rats flown on the COSMOS 2044 mission were compared to the percentage of mitotic cells present in the crypts in rats included in each of 3 ground control groups (i.e., vivarium, synchronous and caudal-elevated). No significant difference (p greater than .05) was detected in mitotic indices between the flight and vivarium group. Although the ability of jejunal mucosal cells to divide by mitosis was not impaired in flight group, there was, however, a reduction in the length of villi and depth of crypts. The concommitant reduction in villus length and crypth depth in the flight group probably reflects changes in connective tissue components within the core of villi.
File Size	364699
Page Count	15
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19930004261
Archival Resource Key	ark:/13960/t4qk2b52c
Language	English
Publisher Date	1991-04-30
Access Restriction	Open
Subject Keyword	Aerospace Medicine Biological Effects Cells Biology Gravitational Effects Mitosis Rats Tissues Biology Biosynthesis Space Flight Microgravity Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Technical Report

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