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Stress antagonizes morphine-induced analgesia in rats
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Vernikos, J. Shannon, L. Heybach, J. P. |
| Copyright Year | 1981 |
| Description | Exposure to restraint stress resulted in antagonism of the analgesic effect of administered morphine in adult male rats. This antagonism of morphine-induced analgesia by restraint stress was not affected by adrenalectomy one day prior to testing, suggesting that stress-induced secretion of corticosteroids is not critical to this antagonism. In addition, parenteral administration of exogenous adrenocorticotropin (ACTH) mimicked the effect of stress in antagonizing morphine's analgesic efficacy. The hypothesis that ACTH is an endogenous opiate antagonist involved in modulating pain sensitivity is supported. |
| File Size | 719765 |
| Page Count | 18 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19810013202 |
| Archival Resource Key | ark:/13960/t3tt9fb6h |
| Language | English |
| Publisher Date | 1981-04-01 |
| Access Restriction | Open |
| Subject Keyword | Pain Sensitivity Analgesia Corticosteroids Rats Adrenocorticotropin Acth Morphine Stress Physiology Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
