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Naloxone inhibits and morphine potentiates. the adrenal steroidogenic response to acth
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Vernikos, J. Heybach, J. P. |
| Copyright Year | 1980 |
| Description | The adrenal actions were stereospecific since neither the positve stereoisomer of morphine, nor that of naloxone, had any effect on the adrenal response to exogenous adrenocorticotrophic hormone (ACTH). The administration of human beta endorphin to phyophysectomized rats had no effect on the adrenal corticosterone concentration nor did it alter the response of the adrenal gland to ACTH. These results indicate that morphine can potentiate the action of ACTH on the adrenal by a direct, stereospecific, dose dependent mechanism that is prevented by naloxone pretreatment and which may involve competition for ACTH receptors on the corticosterone secreting cells of the adrenal cortex. |
| File Size | 594563 |
| Page Count | 17 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19810006092 |
| Archival Resource Key | ark:/13960/t3906xs5k |
| Language | English |
| Publisher Date | 1980-12-01 |
| Access Restriction | Open |
| Subject Keyword | Corticosteroids Nuclear Chemistry Adrenocorticotropin Acth Morphine Adrenal Gland Isomers Adrenal Metabolism Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Technical Report |
