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Effects of hirudin-induced activation of nonenzymatic fibrinolysis during immobilization stress
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Goldovskaya, M. D. Baskova, I. P. Shapiro, F. B. Lyapina, L. A. Cherkesova, L. U. |
| Copyright Year | 1980 |
| Description | The specific inhibitor of thrombin, hirudin, was used for studying the mechanism of the activating effect of ACTH and adrenalin on nonenzymatic fibrinolytic activity (NEFA), the latter characterizing the function of the anticoagulation system (ACS). Simultaneous administration of ACTH and hirudin to animals subjected to immobilization stress did not reduce the effect of ACTH on NEFA, while simultaneous administration of adrenalin and hirudin revealed a diminished effect of the former. This suggests different mechanisms of ACTH and adrenalin effects upon NEFA: the stimulating effect of norepinephrine is realized through throminogenesis followed by activation of the ACS function and by increased NEFA and therefore inhibitable by hirudin which forms an inactive complex with thrombin. In fact the stimulating effect of ACTH upon NEFA is brought about specifically by another route than thrombinogenesis and thus occurs in the presence of hirudin. Hirudin itself has no effect upon NEFA. |
| File Size | 7075502 |
| Page Count | 15 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_19800023558 |
| Archival Resource Key | ark:/13960/t0sr3pm8v |
| Language | English |
| Publisher Date | 1980-07-01 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Enzymes Biological Effects Animals Coagulation Rats Immobilization Adrenocorticotropin Acth Thrombin Hormones Stress Physiology Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
