NDLI: TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome

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Year: 2023 Month: September Volume: 14

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Humoral and cellular immune response and the safety of third SARS-CoV-2 mRNA vaccine with longer interval after the second vaccination in kidney transplant recipients

Long-term survival in extensive-stage small-cell lung cancer treated with different immune checkpoint inhibitors in multiple-line therapies: A case report and literature review

A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity

Resident macrophages of the lung and liver: The guardians of our tissues

Crosstalk of four kinds of cell deaths defines subtypes of cutaneous melanoma for precise immunotherapy and chemotherapy

Corrigendum: Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

A prognostic and therapeutic hallmark developed by the integrated profile of basement membrane and immune infiltrative landscape in lung adenocarcinoma

Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis

Defective antifungal immunity in patients with COVID-19

Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets

Involvement of caveolin-1 in skin diseases

SLC11A1 as a stratification indicator for immunotherapy or chemotherapy in patients with glioma

Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic “fitness” ranges in response to culture process parameters

SFRP4+IGFBP5hi NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain

Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3

The top 100 most cited articles in the last two decades of atopic dermatitis: A bibliometric analysis

H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation

Coagulation- and fibrinolysis-related genes for predicting survival and immunotherapy efficacy in colorectal cancer

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review

Krebs von den lungen-6 as a clinical marker for hypersensitivity pneumonitis: A meta-analysis and bioinformatics analysis

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill

Bacteroides vulgatus attenuates experimental mice colitis through modulating gut microbiota and immune responses

Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma

Mechanism of herpesvirus protein kinase UL13 in immune escape and viral replication

Machine learning-based identification of SOX10 as an immune regulator of macrophage in gliomas

Immune landscape and immunotherapy for penile cancer

Decreased absolute number of peripheral regulatory T cells in patients with idiopathic retroperitoneal fibrosis

Occurrence and role of lung megakaryocytes in infection and inflammation

Dysregulated inflammasome activity in intestinal inflammation – Insights from patients with very early onset IBD

Editorial: Non-coding RNA in immunotherapies and immune regulation

Prognosis stratification in breast cancer and characterization of immunosuppressive microenvironment through a pyrimidine metabolism-related signature

Vesicle-mediated transport-related genes are prognostic predictors and are associated with tumor immunity in lung adenocarcinoma

The prognostic value of the systemic immune-inflammation index for patients with bladder cancer after radical cystectomy

Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus

Case report: CD38-directed CAR-T cell therapy: A novel immunotherapy targeting CD38- positive blasts overcomes TKI and chemotherapy resistance of myeloid chronic myeloid leukemia in blastic phase

C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis

Intranasal inoculation of IFN-λ resolves SARS-CoV-2 lung infection via the rapid reduction of viral burden and improvement of tissue damage

Single-cell RNA-sequencing in asthma research

Case report: Dynamic antibody monitoring in a case of anti-recombinant human erythropoietin-mediated pure red cell aplasia with prolonged course after kidney transplantation

Bioinformatics identification and validation of biomarkers and infiltrating immune cells in endometriosis

Analyzing the immunogenicity of bivalent booster vaccinations in healthcare workers: The SWITCH ON trial protocol

Three-dimensional analyses of vascular network morphology in a murine lymph node by X-ray phase-contrast tomography with a 2D Talbot array

Case report: Daratumumab treatment in pre-transplant alloimmunization and severe hemolytic anemia

Low-dose IL-2 improved clinical symptoms by restoring reduced regulatory T cells in patients with refractory rheumatoid arthritis: A randomized controlled trial

Editorial: Improve metabolic and autoimmune diseases by regulating gut microbiota

Editorial: The role of multi-omics variants in tumor immunity and immunotherapy

Development of a copper metabolism-related gene signature in lung adenocarcinoma

More than meets the eye: The role of microglia in healthy and diseased retina

Regulation and directed inhibition of ECP production by human neutrophils

Human amniotic fluid derived extracellular vesicles attenuate T cell immune response

Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated

AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity

An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants

Case Report: Long-term observations from the tacrolimus weaning randomized clinical trial depicts the challenging aspects for determination of low-immunological risk patients

The impact of aging on intestinal mucosal immune function and clinical applications

An interleukin-1 polymorphism additionally intensified by atopy as prognostic factor for aseptic non-mechanical complications in metal knee and hip arthroplasty

Baseline immune signature score of Tregs × HLA-DR+CD4+ T cells × PD1+CD8+ T cells predicts outcome to immunotherapy in cancer patients

PD-1/LAG-3 bispecific antibody potentiates T cell activation and increases antitumor efficacy

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

Developmental endothelial locus-1 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target

Identification of molecular subtypes based on liquid–liquid phase separation and cross-talk with immunological phenotype in bladder cancer

Altered dental plaque microbiota correlated with salivary inflammation in female methamphetamine users

Assessing the efficacy of immunotherapy in lung squamous carcinoma using artificial intelligence neural network

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis

Case report: Complete response to pembrolizumab in a liver metastatic colon adenocarcinoma patient with a novel likely pathogenic germline MSH2 mutation

Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer

Vanadyl sulfate-enhanced oncolytic virus immunotherapy mediates the antitumor immune response by upregulating the secretion of pro-inflammatory cytokines and chemokines

Editorial: Neuroinflammatory response and brain-peripheral crosstalk after stroke

Genomic analysis of TNF-related genes with prognosis and characterization of the tumor immune microenvironment in lung adenocarcinoma

Characterization of intrahepatic B cells in acute-on-chronic liver failure

HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

Immunogenomic correlates of immune-related adverse events for anti–programmed cell death 1 therapy

Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo

Knockout of IL-6 mitigates cold water-immersion restraint stress-induced intestinal epithelial injury and apoptosis

Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer

Autoimmune hepatitis after COVID-19 vaccination

Mice with lung airway ciliopathy develop persistent Mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased T regulatory cells

Dysregulation of iron metabolism modulators in virologically suppressed HIV-infected patients

Sustained viral response and relapse after discontinuation of oral antiviral drugs in HBeAg-positive patients with chronic hepatitis B infection

Corrigendum: IgG anti-spike antibodies and surrogate neutralizing antibody levels decline faster 3 to 10 months after BNT162b2 vaccination than after SARS-CoV-2 infection in healthcare workers

Simultaneous measurement of multiple variant-specific SARS-CoV-2 neutralizing antibodies with a multiplexed flow cytometric assay

Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity

Comprehensive analysis of anoikis-related long non-coding RNA immune infiltration in patients with bladder cancer and immunotherapy

Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques

Identification of two robust subclasses of sepsis with both prognostic and therapeutic values based on machine learning analysis

Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma

Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4+ effector memory T cells

Criteria for identifying potentially resectable patients with initially oncologically unresectable hepatocellular carcinoma before treatment with lenvatinib plus an anti–PD–1 antibody

SARS-CoV-2 epitopes inform future vaccination strategies

Corrigendum: DCBLD1 Overexpression is associated with a poor prognosis in head and neck squamous cell carcinoma

Porcine sapelovirus 2A protein induces mitochondrial-dependent apoptosis

Platelet signaling at the nexus of innate immunity and rheumatoid arthritis

Intestinal Gasdermins for regulation of inflammation and tumorigenesis

BMAL1/FOXA2-induced rhythmic fluctuations in IL-6 contribute to nocturnal asthma attacks

Applications of single-cell RNA sequencing in atopic dermatitis and psoriasis

Development of a polyamine gene expression score for predicting prognosis and treatment response in clear cell renal cell carcinoma

Establishment of a CRISPR/Cas9 knockout library for screening type I interferon-inducible antiviral effectors in pig cells

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis

Identification and experimental validation of a tumor-infiltrating lymphocytes–related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma

Predictive value of CD3+ cells and interleukin 2 receptor in systemic inflammatory response syndrome after percutaneous nephrolithotomy

Enrichment of T-cell proliferation and memory gene signatures of CD79A/CD40 costimulatory domain potentiates CD19CAR-T cell functions

Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria

Acircadian rhythm-related gene signature for predicting survival and drug response in HNSC

Corrigendum: Lymphatic reconstruction in kidney allograft aggravates chronic rejection by promoting alloantigen presentation

Corrigendum: Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese

Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis

Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice

Plasma adsorption in refractory chronic gouty arthritis flare: A case report

An overview of the effects and mechanisms of m6 A methylation on innate immune cells in sepsis

The impact of soluble HLA-G in IVF/ICSI embryo culture medium on implantation success

Inducing ferroptosis has the potential to overcome therapy resistance in breast cancer

LATPS, a novel prognostic signature based on tumor microenvironment of lung adenocarcinoma to better predict survival and immunotherapy response

A pregnancy hormone-cell death link promotes enhanced lupus-specific immunological effects

Candida albicans V132 induces trained immunity and enhances the responses triggered by the polybacterial vaccine MV140 for genitourinary tract infections

Zanubrutinib plus salvage chemotherapy for relapsed or refractory diffuse large B-cell lymphoma

The usefulness of pretreatment controlling nutritional status score for predicting recurrence in patients with esophageal squamous cell carcinoma undergoing neoadjuvant immunochemotherapy: A real-world study

Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection

PD-L1: Biological mechanism, function, and immunotherapy in gastric cancer

Single-cell transcriptomics in bone marrow delineates CD56dimGranzymeK+ subset as intermediate stage in NK cell differentiation

Modulating macrophage function to reinforce host innate resistance against Mycobacterium avium complex infection

Type I interferon subtypes differentially activate the anti-leukaemic function of natural killer cells

Glucocorticoid receptor hypersensitivity enhances inflammatory signaling and inhibits cell cycle progression in porcine PBMCs

A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants

Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond

Feeding tea polysaccharides affects lipid metabolism, antioxidant capacity and immunity of common carp (Cyprinus carpio L.)

Sex bias in lymphocytes: Implications for autoimmune diseases

Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia

The dual role of the CD95 and CD95L signaling pathway in glioblastoma

Tumor immune microenvironment in endometrial cancer of different molecular subtypes: evidence from a retrospective observational study

Dissecting the impact of molecular T-cell HLA mismatches in kidney transplant failure: A retrospective cohort study

Tumor immunomodulatory effects of polyphenols

Profiling the B cell immune response elicited by vaccination against the respiratory virus SARS-CoV-2

Recent developments in PD-1/PD-L1 blockade research for gastroesophageal malignancies

Crosstalk of angiogenesis-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Weaning stress and intestinal health of piglets: A review

A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice

Sirtuins: Key players in obesity-associated adipose tissue remodeling

Evaluation of the ability of fatty acid metabolism signature to predict response to neoadjuvant chemoradiotherapy and prognosis of patients with locally advanced rectal cancer

The role of the intestinal microbiome in antiphospholipid syndrome

B cell fate mapping reveals their contribution to the memory immune response against helminths

Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177

Increased tumor glycolysis is associated with decreased immune infiltration across human solid tumors

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 3

Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: A preliminary observational study

Cellular immune states in SARS-CoV-2-induced disease

Combinatory local ablation and immunotherapies for hepatocellular carcinoma: Rationale, efficacy, and perspective

Editorial: Revisit the roles of regulatory T cells in infection

Hemoglobin induces inflammation through NF-kB signaling pathway and causes cell oxidative damage in grass carp (Ctenopharyngodon idella)

Characterization of immune microenvironment infiltration and m6A regulator-mediated RNA methylation modification patterns in osteoarthritis

Chitosan particle stabilized Pickering emulsion/interleukin-12 adjuvant system for Pgp3 subunit vaccine elicits immune protection against genital chlamydial infection in mice

Editorial: Innate lymphocytes in tumor surveillance

Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation

A vasculogenic mimicry prognostic signature associated with immune signature in human gastric cancer

Case report: Camrelizumab associated with central retinal vein occlusion

Editorial: Beyond Th1: Novel concepts in tuberculosis vaccine immunology

Humoral and cellular immune responses to Pfizer-BioNTech BNT162b2 SARS-CoV-2 vaccine in adolescents with liver transplantation: Single center experience

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model

Role of endothelial cells in graft-versus-host disease

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies

Hemocytes and fat body cells, the only professional immune cell types in Drosophila, show strikingly different responses to systemic infections

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

Nasal administration of anti-CD3 monoclonal antibody modulates effector CD8+ T cell function and induces a regulatory response in T cells in human subjects

Standardization of neutrophil CD64 and monocyte HLA-DR measurement and its application in immune monitoring in kidney transplantation

Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)

Controversies and expectations for the prevention of GVHD: A biological and clinical perspective

Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration

Editorial: Clinical management, pathogenesis and biomarkers of cardiovascular disease associated with systemic autoimmune disorders

An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy

Nomogram established on account of Lasso-Cox regression for predicting recurrence in patients with early-stage hepatocellular carcinoma

Integrated bioinformatic analysis identified a novel prognostic pan-programmed cell death signature for bladder cancer

The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis

Monoclonal gammopathies of clinical significance (MGCS): In pursuit of optimal treatment

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

Inflamed adipose tissue: A culprit underlying obesity and heart failure with preserved ejection fraction

Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations

Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored

Identification of immune-related features involved in Duchenne muscular dystrophy: A bidirectional transcriptome and proteome-driven analysis

Editorial: Novel mechanisms and approaches in kidney/pancreas-kidney transplant-related injury

Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p

CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil

Corrigendum: Anti-HIV-1 nanobody-IgG1 constructs with improved neutralization potency and the ability to mediate Fc effector functions

Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives

Are homeostatic mechanisms aiding the reconstitution of the T-cell pool during lymphopenia in humans?

Study on liver histopathology of chronic HBV infected patients with different normal ALT values

The osteoblast secretome in Staphylococcus aureus osteomyelitis

Proteomic characteristics of saliva in patients with different subgroups of IgG4-RD

Corrigendum: A potential bioelectromagnetic method to slow down the progression and prevent the development of ultimate pulmonary fibrosis by COVID-19

Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study

Multiplexed engineering and precision gene editing in cellular immunotherapy

A novel signature based on CeRNA and immune status predicts prognostic risk and drug sensitivity in gastric cancer patients

Editorial: The role of monocytes/macrophages in autoimmunity and autoinflammation

N6-methyladenosine regulators-related immune genes enable predict graft loss and discriminate T-cell mediate rejection in kidney transplantation biopsies for cause

The mechanisms underlying the immune control of Zika virus infection at the maternal-fetal interface

Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma

Predictive biomarkers of colon cancer immunotherapy: Present and future

Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts

IL-17A and TNF-α inhibitors induce multiple molecular changes in psoriasis

Advanced primary vaginal squamous cell carcinoma: A case report and literature review

Screening the immune-related circRNAs and genes in mice of spinal cord injury by RNA sequencing

Integrative analysis indicates the prognostic value of circadian rhythm disruption in liver cancer: Potential for therapeutic targeting

Histones: The critical players in innate immunity

Description of CRISPR-Cas9 development and its prospects in human papillomavirus-driven cancer treatment

Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury

SARS-COV-2 infections in inborn errors of immunity: A single center study

Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer

Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Molecular subtypes and a prognostic model for hepatocellular carcinoma based on immune- and immunogenic cell death-related lncRNAs

Human gut microbiota-reactive DP8α regulatory T cells, signature and related emerging functions

Integrated analysis of multiple microarray studies to establish differential diagnostic models of Crohn’s disease and ulcerative colitis based on a metalloproteinase-associated module

Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer

Comparison of dynamic changes in the peripheral CD8+ T cells function and differentiation in ESCC patients treated with radiotherapy combined with anti-PD-1 antibody or concurrent chemoradiotherapy

Editorial: The innate immune system in rheumatoid arthritis

Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system

High-content CRISPR screening in tumor immunology

Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies

Corrigendum: Ligand-based CAR T-cell: Different strategies to drive T-cells in future new treatments

Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors

Identification of immune cell function in breast cancer by integrating multiple single-cell data

The role of Angiogenesis and remodeling (AR) associated signature for predicting prognosis and clinical outcome of immunotherapy in pan-cancer

Platelets’ morphology, metabolic profile, exocytosis, and heterotypic aggregation with leukocytes in relation to severity and mortality of COVID-19-patients

Editorial: Pathogenesis, immune escape, prognosis, and novel management of lymphoid proliferative disorders

Cholesterol: An important actor on the cancer immune scene

Overcoming current challenges to T-cell receptor therapy via metabolic targeting to increase antitumor efficacy, durability, and tolerability

The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective

Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy

Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis

Immunomodulatory regulator blockade in a viral exacerbation model of severe asthma

Preparing for the next pandemic: Simulation-based deep reinforcement learning to discover and test multimodal control of systemic inflammation using repurposed immunomodulatory agents

Divergent dynamics of inflammatory mediators and multiplex PCRs during airway infection in cystic fibrosis patients and healthy controls: Serial upper airway sampling by nasal lavage

The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function

Insights into Acinetobacter baumannii protective immunity

Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs

Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients

Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies

Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice

Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP

Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity

Identification of fatty acid metabolism–related molecular subtype biomarkers and their correlation with immune checkpoints in cutaneous melanoma

Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity

Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps

The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD

Integrated multi-omics reveals novel microbe-host lipid metabolism and immune interactions in the donkey hindgut

Immune response to arbovirus infection in obesity

Differential diagnosis and identification of prognostic markers for peripheral T-cell lymphoma subtypes based on flow cytometry immunophenotype profiles

αDβ2 as a novel target of experimental polymicrobial sepsis

A deep belief network-based clinical decision system for patients with osteosarcoma

Detection and evolutionary dynamics of somatic FAS variants in autoimmune lymphoproliferative syndrome: Diagnostic implications

RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features

The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model

Rapid identification of CMV-specific TCRs via reverse TCR cloning system based on bulk TCR repertoire data

Re-evaluation of mouse models of endometriosis for pathological and immunological research

Transcriptomic study reveals lncRNA-mediated downregulation of innate immune and inflammatory response in the SARS-CoV-2 vaccination breakthrough infections

HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success

Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1–4: A retrospective study

Protective immunity enhanced Salmonella vaccine vectors delivering Helicobacter pylori antigens reduce H. pylori stomach colonization in mice

Identification of novel immune correlates of protection against acute bovine babesiosis by superinfecting cattle with in vitro culture attenuated and virulent Babesia bovis strains

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Systemic immune-inflammation index is associated with hepatic steatosis: Evidence from NHANES 2015-2018

Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa

The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment

Regulation of differentiation and generation of osteoclasts in rheumatoid arthritis

IFITM protein regulation and functions: Far beyond the fight against viruses

In vitro systems to study inborn errors of immunity using human induced pluripotent stem cells

Editorial: Insights in antigen presenting cell biology: 2021

What role for cellular metabolism in the control of hepatitis viruses?

Novel T-cell signature based on cell pair algorithm predicts survival and immunotherapy response for patients with bladder urothelial carcinoma

“Liquid biopsy” - extracellular vesicles as potential novel players towards precision medicine in asthma

What do animal models tell us about the role of EBV in the pathogenesis of multiple sclerosis?

The effect of organ-specific tumor microenvironments on response patterns to immunotherapy

M2 macrophage-related gene signature in chronic rhinosinusitis with nasal polyps

In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns

Memory-like innate lymphoid cells in the pathogenesis of asthma

T cell-intrinsic protein kinase D3 is dispensable for the cells’ activation

Multiple CAR-T cell therapy for acute B-cell lymphoblastic leukemia after hematopoietic stem cell transplantation: A case report

Pathologic responses and surgical outcomes after neoadjuvant immunochemotherapy versus neoadjuvant chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma

Effects of cysteine addition to low-fishmeal diets on the growth, anti-oxidative stress, intestine immunity, and Streptococcus agalactiae resistance in juvenile golden pompano (Trachinotus ovatus)

Immuno-cardio-oncology: Killing two birds with one stone?

Identification of immune infiltration and cuproptosis-related subgroups in Crohn’s disease

Prognostic value of 18F-FDG PET/CT in patients with advanced or metastatic non-small-cell lung cancer treated with immune checkpoint inhibitors: A systematic review and meta-analysis

Photodynamic therapy improves the clinical efficacy of advanced colorectal cancer and recruits immune cells into the tumor immune microenvironment

Why vaccines fail against Piscirickettsiosis in farmed salmon and trout and how to avoid it: A review

Prospective longitudinal analysis of antibody response after standard and booster doses of SARS-COV2 vaccination in patients with early breast cancer

Radiotherapy plus CAR-T cell therapy to date: A note for cautions optimism?

Monocyte adaptations in patients with obesity during a 1.5 year lifestyle intervention

Research progress in inducing immunogenic cell death of tumor cells

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Single cell sequencing revealed the mechanism of PD-1 resistance affected by the expression profile of peripheral blood immune cells in ESCC

Case Report: Mutations in JAK3 causing severe combined immunodeficiency complicated by disseminated Bacille Calmette–Guérin disease and Pneumocystis pneumonia

Human lymphoid tissue sampling for vaccinology

Neutrophil extracellular traps and complications of liver transplantation

Differentially induced immunity in buccal and nasal mucosae after vaccination for SARS–CoV–2: Prospects for mass scale immunity-screening in large populations

Age-dependent NK cell dysfunctions in severe COVID-19 patients

Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications

Combined bulk RNA-seq and single-cell RNA-seq identifies a necroptosis-related prognostic signature associated with inhibitory immune microenvironment in glioma

Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice

Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Comprehensive 18F-FDG PET-based radiomics in elevating the pathological response to neoadjuvant immunochemotherapy for resectable stage III non-small-cell lung cancer: A pilot study

Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis

Hepatitis B functional cure and immune response

The immunosuppressive microenvironment and immunotherapy in human glioblastoma

Response of immunoglobulin M in gut mucosal immunity of common carp (Cyprinus carpio) infected with Aeromonas hydrophila

CARARIME: Interactive web server for comprehensive analysis of renal allograft rejection in immune microenvironment

Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Hemocyte response to treatment of susceptible and resistant Asian corn borer (Ostrinia furnacalis) larvae with Cry1F toxin from Bacillus thuringiensis

Construction and validation of an angiogenesis-related scoring model to predict prognosis, tumor immune microenvironment and therapeutic response in hepatocellular carcinoma

Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

Systematic pan-cancer analysis identifies RALA as a tumor targeting immune therapeutic and prognostic marker

Low fish meal diet supplemented with probiotics ameliorates intestinal barrier and immunological function of Macrobrachium rosenbergii via the targeted modulation of gut microbes and derived secondary metabolites

The adaptive immune system in early life: The shift makes it count

The associations of maternal and children’s gut microbiota with the development of atopic dermatitis for children aged 2 years

Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy

Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies

Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of Anoplocephala perfoliata

CNS and CNS diseases in relation to their immune system

Gata3ZsG and Gata3ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

Recent progress and perspectives on the relationship between hyperuricemia and periodontitis

The dichotomous outcomes of TNFα signaling in CD4+ T cells

Multiplex flow cytometry-based assay for quantifying tumor- and virus-associated antibodies induced by immunotherapies

A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4+ T cell vaccine efficiently enhances anti-leukemia immunity

Single-cell sequencing reveals the landscape of the tumor microenvironment in a skeletal undifferentiated pleomorphic sarcoma patient

Integrated multi-omics analysis identifies CD73 as a prognostic biomarker and immunotherapy response predictor in head and neck squamous cell carcinoma

Estimation of anti-orthopoxvirus immunity in Moscow residents and potential risks of spreading Monkeypox virus

The published trend of studies on COVID-19 and dietary supplements: Bibliometric analysis

Elevation of circulating TNF receptor 2 in cancer: A systematic meta-analysis for its potential as a diagnostic cancer biomarker

Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

Emerging insights and challenges for understanding T cell function through the proteome

Heterogeneity of neutrophils and inflammatory responses in patients with COVID-19 and healthy controls

Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion

Brain-gut axis and psychiatric disorders: A perspective from bibliometric and visual analysis

Development and validation of immunogenic cell death-related signature for predicting the prognosis and immune landscape of uveal melanoma

Combined impact of the inter and intra-patient variability of tacrolimus blood level on allograft outcomes in kidney transplantation

A novel necroptosis-related lncRNA signature for predicting prognosis and anti-cancer treatment response in endometrial cancer

Tissue-resident memory T cells in the era of (Neo) adjuvant melanoma management

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection

Orofacial clefts lead to increased pro-inflammatory cytokine levels on neonatal oral mucosa

Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer

An intranasal vaccine targeting the receptor binding domain of SARS-CoV-2 elicits a protective immune response

Perturbations of the T-cell immune repertoire in kidney transplant rejection

Editorial: The complement system in autoimmunity

Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases

Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease

Microglia autophagy in ischemic stroke: A double-edged sword

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Clinical characteristics of the host DNA-removed metagenomic next-generation sequencing technology for detecting SARS-CoV-2, revealing host local immune signaling and assisting genomic epidemiology

Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis

Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma

NETosis is critical in patients with severe community-acquired pneumonia

Constrast-enhanced computed tomography radiomics predicts CD27 expression and clinical prognosis in head and neck squamous cell carcinoma

CAR T-cells for colorectal cancer immunotherapy: Ready to go?

Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

A cellular senescence-related classifier based on a tumorigenesis- and immune infiltration-guided strategy can predict prognosis, immunotherapy response, and candidate drugs in hepatocellular carcinoma

Development and external validation of a novel nomogram model for predicting postoperative recurrence-free survival in non-muscle-invasive bladder cancer

Analysis of T cell repertoires of CD45RO CD4 T cells in cohorts of patients with bullous pemphigoid: A pilot study

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

Case report: The remarkable response of pembrolizumab combined with RC48 in the third-line treatment of metastatic urothelial carcinoma

MSCs interaction with the host lung microenvironment: An overlooked aspect?

Lower dose of ATG combined with basiliximab for haploidentical hematopoietic stem cell transplantation is associated with effective control of GVHD and less CMV viremia

Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation

Harnessing the small intestinal axis to resolve systemic inflammation

Understanding AL amyloidosis with a little help from in vivo models

Nectin4 is a potential therapeutic target for asthma

The m6A methylation profiles of immune cells in type 1 diabetes mellitus

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation

Multiple sclerosis and obesity: The role of adipokines

Circulating mitochondrial cell-free DNA dynamics in patients with mycobacterial pulmonary infections: Potential for a novel biomarker of disease

Antiviral response within different cell types of the CNS

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

Serological responses triggered by different SARS-CoV-2 vaccines against SARS-CoV-2 variants in Taiwan

Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals

Extracellular vesicle-derived miRNAs improve stem cell-based therapeutic approaches in muscle wasting conditions

Increased peripheral inflammatory responses in myelin oligodendrocyte glycoprotein associated disease and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder

Immunomodulatory effects of two recombinant arginine kinases in Sarcoptes Scabiei on host peripheral blood mononuclear cells

The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis

Challenges in diagnostic testing of nephritic factors

PD-L1 is upregulated in CD163+ tonsillar macrophages from children undergoing EBV primary infection

The Effect of immunotherapy on oligometastatic non-small cell lung cancer patients by sites of metastasis

Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms

Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

Unbalanced networks and disturbed kinetics of serum soluble mediators associated with distinct disease outcomes in severe COVID-19 patients

Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy

Pilot genome-wide association study of antibody response to inactivated SARS-CoV-2 vaccines

Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes

Characterization of immune checkpoint inhibitor-associated fulminant type 1 diabetes associated with autoantibody status and ethnic origin

A minimally-edited mouse model for infection with multiple SARS-CoV-2 strains

C-Reactive Protein (CRP): A poor prognostic biomarker in COVID-19

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions

Comparative study of subcutaneous, intramuscular, and oral administration of bovine pathogenic Escherichia coli bacterial ghost vaccine in mice

Case report: Novel FHR2 variants in atypical Hemolytic Uremic Syndrome: A case study of a translational medicine approach in renal transplantation

Autoantibodies as biomarkers for breast cancer diagnosis and prognosis

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia

Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors

A novel cuproptosis-related lncRNA signature predicts the prognosis and immune landscape in bladder cancer

Complex interaction and heterogeneity among cancer stem cells in head and neck squamous cell carcinoma revealed by single-cell sequencing

Dynamics of humoral immune response in SARS-CoV-2 infected individuals with different clinical stages

Cytokine expression in rhinovirus- vs. respiratory syncytial virus-induced first wheezing episode and its relation to clinical course

The predictive value of peripheral blood cells and lymphocyte subsets in oesophageal squamous cell cancer patients with neoadjuvant chemoradiotherapy

Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines

Real-world landscape transition of death causes in the immunotherapy era for metastatic non-small cell lung cancer

Efficacy and safety of copanlisib in relapsed/refractory B-cell non-Hodgkin lymphoma: A meta-analysis of prospective clinical trials

Tailoring biomaterials and applications targeting tumor-associated macrophages in cancers

Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis

Inhibition of the CD47-SIRPα axis for cancer therapy: A systematic review and meta-analysis of emerging clinical data

Editorial: Unveiling immunological mechanisms of periodontal diseases

Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing

Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice

Indoleamine 2,3-dioxygenase 1 signaling orchestrates immune tolerance in Echinococcus multilocularis-infected mice

Listeria-based immunotherapy directed against CD105 exerts anti-angiogenic and anti-tumor efficacy in renal cell carcinoma

Narrowband ultraviolet B response in cutaneous T-cell lymphoma is characterized by increased bacterial diversity and reduced Staphylococcus aureus and Staphylococcus lugdunensis

Vedolizumab for acute gastrointestinal graft-versus-host disease: A systematic review and meta-analysis

Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells

Exploring the molecular mechanism of hepatitis virus inducing hepatocellular carcinoma by microarray data and immune infiltrates analysis

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

Single-dose of a replication-competent adenovirus-vectored vaccine provides sterilizing protection against Rift Valley fever virus challenge

Integrativesubtractive proteomics, immunoinformatics, docking, and simulation approaches reveal candidate vaccine against Sin Nombre orthohantavirus

NFIL3 and its immunoregulatory role in rheumatoid arthritis patients

Artificial intelligence for precision medicine in autoimmune liver disease

Implication of platelets and complement C3 as link between innate immunity and tubulointerstitial injury in renal vasculitis with MPO-ANCA seropositivity

Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis

Adjuvant alternative cytokine-induced killer cell combined with natural killer cell immunotherapy improves the prognosis of post-mastectomy breast cancer

Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy

Assessing organ-level immunoreactivity in a rat model of sepsis using TSPO PET imaging

Single-cell transcriptomic characterization reveals the landscape of airway remodeling and inflammation in a cynomolgus monkey model of asthma

TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome

The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease

A randomized controlled trial to verify the irrigation of salivary glands in relieving xerostomia in patients with Sjögren’s syndrome

Immunometabolism in the pathogenesis of vitiligo

Analysis of signature genes and association with immune cells infiltration in pediatric septic shock

IgA in human health and diseases: Potential regulator of commensal microbiota

CD11c regulates late-stage T cell development in the thymus

Manipulation of the crosstalk between tumor angiogenesis and immunosuppression in the tumor microenvironment: Insight into the combination therapy of anti-angiogenesis and immune checkpoint blockade

Corrigendum: Low-molecular-weight heparin versus aspirin in early management of acute ischemic stroke: A systematic review and meta-analysis

Current status and development prospects of aquatic vaccines

Characterization of chemokine and cytokine expression pattern in tuberculous lymphadenitis patient

A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins

Crosslinking of membrane CD13 in human neutrophils mediates phagocytosis and production of reactive oxygen species, neutrophil extracellular traps and proinflammatory cytokines

Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery

Toxicity profile of combined immune checkpoint inhibitors and thoracic radiotherapy in esophageal cancer: A meta-analysis and systematic review

Peripheral ulcerative keratitis, nodular episcleritis, and pulmonary nodules as the initial signs of rheumatic arthritis: A Case Report

Case report: Local cryoablation combined with pembrolizumab to eliminate lung metastases from ovarian clear cell carcinoma

Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity

Spatial architecture of regulatory T-cells correlates with disease progression in patients with nasopharyngeal cancer

In silico analysis of alternative splicing events implicated in intracellular trafficking during B-lymphocyte differentiation

TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization

Barcode clonal tracking of tissue-resident immune cells in rhesus macaque highlights distinct clonal distribution pattern of tissue NK cells

Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

Spatiotemporal characteristics of P-selectin-induced β2 integrin activation of human neutrophils under flow

Cellular and humoral immune response between snail hosts and their parasites

Autologous organoid co-culture model reveals T cell-driven epithelial cell death in Crohn’s Disease

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

ALT-803 in the treatment of non-muscle-invasive bladder cancer: Preclinical and clinical evidence and translational potential

miR-142 favors naïve B cell residence in peripheral lymph nodes

Phase separation drives the formation of biomolecular condensates in the immune system

Sleeping beauty generated CD19 CAR T-Cell therapy for advanced B-Cell hematological malignancies

Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells

Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets

1270 nm near-infrared light as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines

Research progress on anti-ovarian cancer mechanism of miRNA regulating tumor microenvironment

Hypersensitivity reactions to small molecule drugs

Central nervous system commitment in Chagas disease

Dorsal switch protein 1 as a damage signal in insect gut immunity to activate dual oxidase via an eicosanoid, PGE2

Remodeling tumor microenvironment with natural products to overcome drug resistance

Antiviral prophylaxis or preemptive therapy for cytomegalovirus after liver transplantation?: A systematic review and meta-analysis

A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™)

Predictive models for thromboembolic events in giant cell arteritis: A US veterans health administration population-based study

ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases

Non-replicative antibiotic resistance-free DNA vaccine encoding S and N proteins induces full protection in mice against SARS-CoV-2

SARS-CoV-2-specific humoral and cellular immune responses to BNT162b2 vaccine in Fibrodysplasia ossificans progressiva patients

Association between systemic rheumatic diseases and dementia risk: A meta-analysis

The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model

Proposed new prognostic model using the systemic immune-inflammation index for primary central nervous system lymphoma: A prospective-retrospective multicohort analysis

CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types

SILAC-based quantitative proteomics and microscopy analysis of cancer cells treated with the N-glycolyl GM3-specific anti-tumor antibody 14F7

Efferocytosis drives myeloid NLRP3 dependent inflammasome signaling secretion of IL-1β to promote tumor growth

Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches

Characterization of exosomes derived from IPEC-J2 treated with probiotic Bacillus amyloliquefaciens SC06 and its regulation of macrophage functions

Analysis of macular structure in age-related cataract patients with different antibody levels of severe acute respiratory syndrome coronavirus-2 vaccine

Role of FK506-sensitive signals in asthmatic lung inflammation

Editorial: The role of immune cells in the progression of autoimmune diseases affecting the CNS

Immune-profiling of SARS-CoV-2 viremic patients reveals dysregulated innate immune responses

Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation

Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression

A recombinant Artemisia vulgaris pollen adjuvanted Art v 1 protein-based vaccine treats allergic rhinitis and bronchial asthma using pre- and co-seasonal ultrashort immunotherapy regimens in sensitized mice

Corrigendum: Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis

A longitudinal study of C1q and anti-C1q autoantibodies in homologous and heterologous pregnancies for predicting pre-eclampsia

ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

A vaccine based on the yeast-expressed receptor-binding domain (RBD) elicits broad immune responses against SARS-CoV-2 variants

Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment

Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis

Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders

The relation of the frequency and functional molecules expression on plasmacytoid dendritic cells to postpartum hepatitis in women with HBeAg-positive chronic hepatitis B virus infection

Heparin is required for the formation of granules in connective tissue mast cells

Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2

Splenic protection network revealed by transcriptome analysis in inactivated vaccine-immunized flounder (Paralichthys olivaceus) against Edwardsiella tarda infection

Identification and validation of novel biomarkers affecting bladder cancer immunotherapy via machine learning and its association with M2 macrophages

Viral tropism for the testis and sexual transmission

Chromomycin A5 induces bona fide immunogenic cell death in melanoma

Mesenchymal stromal cells as treatment for acute respiratory distress syndrome. Case Reports following hematopoietic cell transplantation and a review

Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice

Oropharyngeal tumor cells induce COX-2 expression in peripheral blood monocytes by secretion of IL-1α

Probiotics modulate gastrointestinal microbiota after Helicobacter pylori eradication: A multicenter randomized double-blind placebo-controlled trial

Effects of gut microbiota on immune responses and immunotherapy in colorectal cancer

Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients

Translating the observed differences in interleukin-6 levels between some antiretroviral regimens into potential long-term risk of serious non-AIDS events: A modeling study

Benchmarking freely available HLA typing algorithms across varying genes, coverages and typing resolutions

Degree of stemness predicts micro-environmental response and clinical outcomes of diffuse large B-cell lymphoma and identifies a potential targeted therapy

ROS and DNA repair in spontaneous versus agonist-induced NETosis: Context matters

A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells

The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation

Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella

Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface

Fibroblast growth factor receptor family mutations as a predictive biomarker for immune checkpoint inhibitors and its correlation with tumor immune microenvironment in melanoma

Applications of nanobodies in brain diseases

Safety and immunogenicity of heterologous recombinant protein subunit vaccine (ZF2001) booster against COVID-19 at 3–9-month intervals following two-dose inactivated vaccine (CoronaVac)

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

Identification of potential candidate vaccines against Mycobacterium ulcerans based on the major facilitator superfamily transporter protein

Ex vivo cytokine production in psoriatic disease: Towards specific signatures in cutaneous psoriasis and peripheral psoriatic arthritis

Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells

Microglial cells: Sensors for neuronal activity and microbiota-derived molecules

CD4+CD25+ T regulatory cells in renal transplantation

Human papillomavirus infection can alter the level of tumour stemness and T cell infiltration in patients with head and neck squamous cell carcinoma

Tertiary lymphoid structure patterns aid in identification of tumor microenvironment infiltration and selection of therapeutic agents in bladder cancer

Identification of prognostic immune-related lncRNAs in pancreatic cancer

Elucidating the mitochondrial function of murine lymphocyte subsets and the heterogeneity of the mitophagy pathway inherited from hematopoietic stem cells

Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers

Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner

Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study

Exosomal ncRNAs: The pivotal players in diabetic wound healing

Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers

Bioinformatics and systems biology approaches to identify molecular targeting mechanism influenced by COVID-19 on heart failure

Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections

Corrigendum: Plasma exosomal IRAK1 can be a potential biomarker for predicting the treatment response to renin-angiotensin system inhibitors in patients with IgA nephropathy

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis

Dietary supplementation with Tolypocladium sinense mycelium prevents dyslipidemia inflammation in high fat diet mice by modulation of gut microbiota in mice

Single-cell profiling to transform immunotherapy usage and target discovery in immune-mediated inflammatory diseases

Implications of rituximab pharmacokinetic and pharmacodynamic alterations in various immune-mediated glomerulopathies and potential anti-CD20 therapy alternatives

Immune profiling identifies CD8+ T-cell subset signatures as prognostic markers for recurrence in papillary thyroid cancer

CD160 receptor in CLL: Current state and future avenues

Deep learning to estimate durable clinical benefit and prognosis from patients with non-small cell lung cancer treated with PD-1/PD-L1 blockade

Immunoregulatory effects of RGMb in gut inflammation

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

Relationships of circulating CD4+ T cell subsets and cytokines with the risk of relapse in patients with Crohn’s disease

Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs

Mesenchymal stromal cell extracellular vesicles for multiple sclerosis in preclinical rodent models: A meta-analysis

Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung

Editorial: The role of immune cells in hepatic ischemia reperfusion

Editorial: Epigenetics of infectious diseases

Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

Activation of distinct antiviral T-cell immunity: A comparison of bi- and trispecific T-cell engager antibodies with a chimeric antigen receptor targeting HBV envelope proteins

From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis

Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19

Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer

Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus

NLRP3+ macrophages aggravate inflammatory cystitis in diabetes

The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection

Autoimmunity: Are we asking the right question?

Identifying tumor antigens and immune subtypes of renal cell carcinoma for immunotherapy development

IgG subclass and Fc glycosylation shifts are linked to the transition from pre- to inflammatory autoimmune conditions

Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury

SMO mutation predicts the effect of immune checkpoint inhibitor: From NSCLC to multiple cancers

Identification of CKS1B as a prognostic indicator and a predictive marker for immunotherapy in pancreatic cancer

Interleukin-6 and indoleamine-2,3-dioxygenase as potential adjuvant targets for Papillomavirus-related tumors immunotherapy

The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy

Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models

A broad cuproptosis landscape in inflammatory bowel disease

Targeted drug delivery system for ovarian cancer microenvironment: Improving the effects of immunotherapy

Expanding spectrum, intrafamilial diversity, and therapeutic challenges from 15 patients with heterozygous CARD11-associated diseases: A single center experience

Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab

The role of IL-38 in intestinal diseases - its potential as a therapeutic target

NKB cells: A double-edged sword against inflammatory diseases

Mast cells as important regulators in the development of psoriasis

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation

Low dose versus standard dose rituximab for the treatment of antiphospholipid syndrome: A pilot study from a tertiary medical center

Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report

Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies

Prognostic value of γ‐aminobutyric acidergic synapse-associated signature for lower-grade gliomas

Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation

NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model

Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection

Regulation of hematopoietic and leukemia stem cells by regulatory T cells

The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy

Identification of diagnostic genes for both Alzheimer’s disease and Metabolic syndrome by the machine learning algorithm

Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome

The derived neutrophil to lymphocyte ratio can be the predictor of prognosis for COVID-19 Omicron BA.2 infected patients

Vessel state and immune infiltration of the angiogenesis subgroup and construction of a prediction model in osteosarcoma

Anticardiolipin and/or anti-β2-glycoprotein-I antibodies are associated with adverse IVF outcomes

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation

Immuno-informatics profiling of monkeypox virus cell surface binding protein for designing a next generation multi-valent peptide-based vaccine

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?

HSP90AA1 interacts with CSFV NS5A protein and regulates CSFV replication via the JAK/STAT and NF-κB signaling pathway

Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression

Inducible costimulator ligand (ICOSL) on CD19+ B cells is involved in immunopathological damage of rheumatoid arthritis (RA)

The yin/yang balance of the MHC-self-immunopeptidome

Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell

A nomogram model based on the number of examined lymph nodes–related signature to predict prognosis and guide clinical therapy in gastric cancer

Implications of m6A-associated snRNAs in the prognosis and immunotherapeutic responses of hepatocellular carcinoma

Analyzing some concepts of immune regulation of the last three decades: Fostering greater research resilience despite the information overload. A personal view

Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer

Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction

Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Characterization of immunomodulatory responses induced by manuka honey

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment

Roles and crosstalks of macrophages in diabetic nephropathy

Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer

SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies

Leverage biomaterials to modulate immunity for type 1 diabetes

Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli

Alzheimer’s disease alters the transcriptomic profile of natural killer cells at single-cell resolution

Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors

Editorial: The role of omics characteristics in the diagnosis, treatment, and prognosis of autoimmune diseases

Integrating bulk and single-cell sequencing reveals the phenotype-associated cell subpopulations in sepsis-induced acute lung injury

Sex-related differences in the response of anti-platelet drug therapies targeting purinergic signaling pathways in sepsis

Interplay between programmed death-ligand 1 and non-coding RNAs

Increased monocyte abundance as a marker for relapse after discontinuation of biologics in inflammatory bowel disease with deep remission

Effect of the m6ARNA gene on the prognosis of thyroid cancer, immune infiltration, and promising immunotherapy

MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy

ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

Combining all-trans retinoid acid treatment targeting myeloid-derived suppressive cells with cryo-thermal therapy enhances antitumor immunity in breast cancer

Establishment and analysis of a disease risk prediction model for the systemic lupus erythematosus with random forest

Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques

IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6

Single-cell atlas of murine adrenal glands reveals immune-adrenal crosstalk during systemic Candida albicans infection

Identification and validation of a classifier based on hub aging-related genes and aging subtypes correlation with immune microenvironment for periodontitis

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Immune infiltration in aggressive papillary craniopharyngioma: High infiltration but low action

The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study

Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling

Insulin-binding protein-5 down-regulates the balance of Th17/Treg

The neonatal Fc receptor expression during macrophage differentiation is related to autophagy

The analysis of the pyroptosis-related genes and hub gene TP63 ceRNA axis in osteosarcoma

Bispecific antibody-targeted T-cell therapy for acute myeloid leukemia

Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy

Environmentally-triggered contraction of the norovirus virion determines diarrheagenic potential

Editorial: The role of leukocyte extracellular traps in Inflammation and autoimmunity

Year: 2022 Month: October Volume: 13

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TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome

Content Provider	frontiers
Author	Carrara, Stefania C. Harwardt, Julia Grzeschik, Julius Hock, Björn Kolmar, Harald
Abstract	Harnessing the innate power of T cells for therapeutic benefit has seen many shortcomings due to cytotoxicity in the past, but still remains a very attractive mechanism of action for immune-modulating biotherapeutics. With the intent of expanding the therapeutic window for T-cell targeting biotherapeutics, we present an attenuated trispecific T-cell engager (TCE) combined with an anti- interleukin 6 receptor (IL-6R) binding moiety in order to modulate cytokine activity (TriTECM). Overshooting cytokine release, culminating in cytokine release syndrome (CRS), is one of the severest adverse effects observed with T-cell immunotherapies, where the IL-6/IL-6R axis is known to play a pivotal role. By targeting two tumour-associated antigens, epidermal growth factor receptor (EGFR) and programmed death ligand 1 (PD-L1), simultaneously with a bispecific two-in-one antibody, high tumour selectivity together with checkpoint inhibition was achieved. We generated tetrafunctional molecules that contained additional CD3- and IL-6R-binding modules. Ligand competition for both PD-L1 and IL-6R as well as inhibition of both EGF- and IL-6-mediated signalling pathways was observed. Furthermore, TriTECM molecules were able to activate T cells and trigger T-cell-mediated cytotoxicity through CD3-binding in an attenuated fashion. A decrease in pro-inflammatory cytokine interferon γ (IFNγ) after T-cell activation was observed for the TriTECM molecules compared to their respective controls lacking IL-6R binding, hinting at a successful attenuation and potential modulation via IL-6R. As IL-6 is a key player in cytokine release syndrome as well as being implicated in enhancing tumour progression, such molecule designs could reduce side effects and cytotoxicity observed with previous TCEs and widen their therapeutic windows.
ISSN	16643224
DOI	10.3389/fimmu.2022.1051875
Volume Number	13
Journal	Frontiers in Immunology
Language	English
Publisher Date	2022-11-10
Access Restriction	Open
Subject Keyword	Multispecific antibody Tetraspecifics CRS T-cell engager IL-6R Cytokine release syndrome
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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