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| Content Provider | frontiers |
|---|---|
| Author | Eichholz, Thomas Döring, Michaela Giardino, Stefano Gruhn, Bernd Seitz, Christian Flaadt, Tim Schwinger, Wolfgang Ebinger, Martin Holzer, Ursula Mezger, Markus Teltschik, Heiko-Manuel Sparber-Sauer, Monika Koscielniak, Ewa Abele, Michael Handgretinger, Rupert Lang, Peter |
| Abstract | BackgroundPrognosis of children with primary disseminated or metastatic relapsed sarcomas remains dismal despite intensification of conventional therapies including high-dose chemotherapy. Since haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is effective in the treatment of hematological malignancies by mediating a graft versus leukemia effect, we evaluated this approach in pediatric sarcomas as well.MethodsPatients with bone Ewing sarcoma or soft tissue sarcoma who received haplo-HSCT as part of clinical trials using CD3+ or TCRα/β+ and CD19+ depletion respectively were evaluated regarding feasibility of treatment and survival.ResultsWe identified 15 patients with primary disseminated disease and 14 with metastatic relapse who were transplanted from a haploidentical donor to improve prognosis. Three-year event-free survival (EFS) was 18,1% and predominantly determined by disease relapse. Survival depended on response to pre-transplant therapy (3y-EFS of patients in complete or very good partial response: 36,4%). However, no patient with metastatic relapse could be rescued.ConclusionHaplo-HSCT for consolidation after conventional therapy seems to be of interest for some, but not for the majority of patients with high-risk pediatric sarcomas. Evaluation of its future use as basis for subsequent humoral or cellular immunotherapies is necessary. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2023.1064190 |
| Volume Number | 13 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2023-02-21 |
| Access Restriction | Open |
| Subject Keyword | Haploidentical hematopoietic stem cell transplantation Ewing sarcoma Rhabdomyosarcoma Pediatric sarcoma Soft Tissue Sarcoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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