NDLI: Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death

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Year: 2023 Month: September Volume: 13

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Automatic quality assurance of radiotherapy treatment plans using Bayesian networks: A multi-institutional study

Intravoxel incoherent motion imaging used to assess tumor microvascular changes after transarterial chemoembolization in a rabbit VX2 liver tumor model

Transarterial chemoembolization as an alternative to radioembolization is associated with earlier tumor recurrence than in radioembolization-eligible patients

Development and validation of a MRI-based combined radiomics nomogram for differentiation in chondrosarcoma

Metabolic classification of non-small cell lung cancer patient-derived xenografts by a digital pathology approach: A pilot study

Segmentation stability of human head and neck cancer medical images for radiotherapy applications under de-identification conditions: Benchmarking data sharing and artificial intelligence use-cases

The association of cemiplimab plus sonidegib for synchronous cutaneous squamous cell carcinoma and basal cell carcinoma of the head and neck: Two case reports

Combining distance and anatomical information for deep-learning based dose distribution predictions for nasopharyngeal cancer radiotherapy planning

Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway

Notch-Jagged1 signaling and response to bevacizumab therapy in advanced colorectal cancer: A glance to radiomics or back to physiopathology?

The effect of gastric fundus radiation dose on postoperative anastomotic leakage in esophageal cancer

Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer

The implications and prospect of cuproptosis-related genes and copper transporters in cancer progression

Baseline risk factors associated with immune related adverse events and atezolizumab

Adjuvant chemotherapy compared with observation in patients with T2aN0 stage IB lung adenocarcinoma

Progression in immunotherapy for advanced prostate cancer

Need for close interdisciplinary communication after endoscopic endonasal surgery to further personalize postoperative radiotherapy in sinonasal malignancies

Comparison of the endoscopic thyroidectomy via areola approach and open thyroidectomy: A propensity score matched cohort study of 302 patients in the treatment of papillary thyroid non-microcarcinoma

Distribution of residual tumors in esophageal squamous cell carcinoma after neoadjuvant PD-1 blockade combined with chemotherapy

Identification of predictive factors for outcomes after robot-assisted partial nephrectomy based on three-dimensional reconstruction of preoperative enhanced computerized tomography

Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma

Editorial: Advances in the treatment of Hodgkin lymphoma

On the importance of interpretable machine learning predictions to inform clinical decision making in oncology

Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients

The gene regulatory molecule GLIS3 in gastric cancer as a prognostic marker and be involved in the immune infiltration mechanism

Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates

Clinical management of molecular alterations identified by high throughput sequencing in patients with advanced solid tumors in treatment failure: Real-world data from a French hospital

Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas

Prediction models for chronic postsurgical pain in patients with breast cancer based on machine learning approaches

Reduced radiation exposure to circulating blood cells in proton therapy compared with X-ray therapy in locally advanced lung cancer: Computational simulation based on circulating blood cells

Hereditary predisposition to malignant myeloid hemopathies: Caution in use of saliva and guideline based on our experience

Hepatectomy versus transcatheter arterial chemoembolization for resectable BCLC stage A/B hepatocellular carcinoma beyond Milan criteria: A randomized clinical trial

The comparison of manual and mechanical anastomosis after total pharyngolaryngoesophagectomy

Clinicopathological characteristics and treatment outcome of resectable gastric cancer patients with small para-aortic lymph node

Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZ

Case report: A case of delayed cutaneous metastases from signet-ring cell mixed-type gastric cancer

Serological and cellular response to mRNA-SARS-CoV2 vaccine in patients with hematological lymphoid malignancies: Results of the study “Cervax”

Overcoming CEP85L-ROS1, MKRN1-BRAF and MET amplification as rare, acquired resistance mutations to Osimertinib

JAG1 is correlated to suppressive immune microenvironment and predicts immunotherapy resistance in lung adenocarcinoma

Roles of lncRNAs in childhood cancer: Current landscape and future perspectives

PARP inhibitor-related haemorrhages: What does the real-world study say?

Prognostic risk factors and nomogram construction for sebaceous carcinoma: A population-based analysis

Effects of individualized dietary counseling on nutritional status and quality of life in post-discharge patients after surgery for gastric cancer: A randomized clinical trial

Primary refractory plasmablastic lymphoma: A precision oncology approach

Risk factor analysis and construction of prediction models of gallbladder carcinoma in patients with gallstones

A nomogram prediction model for lymph node metastasis risk after neoadjuvant chemoradiotherapy in rectal cancer patients based on SEER database

Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors

An updated portrait of monocyte-macrophages in classical Hodgkin lymphoma

Editorial: GBM stem cells and the brain tumor microenvironment

Case Report: Extraskeletal osteosarcoma with preceding myositis ossificans

Early calcitonin levels in medullary thyroid carcinoma: Prognostic role in patients without distant metastases at diagnosis

Research on automatic classification technology of kidney tumor and normal kidney tissue based on computed tomography radiomics

Editorial: Advances in the understanding of pathogenesis, diagnosis, and therapy of light chain amyloidosis

Sporadic spinal psammomatous malignant melanotic nerve sheath tumor: A case report and literature review

Single progesterone receptor-positive phenotype has the similar clinicopathological features and outcome as triple-negative subtype in metastatic breast cancer

A promising new cancer marker: Long noncoding RNA EGFR-AS1

Perioperative lidocaine and dexmedetomidine intravenous infusion reduce the serum levels of NETs and biomarkers of tumor metastasis in lung cancer patients: A prospective, single-center, double-blinded, randomized clinical trial

Preoperative hydronephrosis is an independent protective factor of renal function decline after nephroureterectomy for upper tract urothelial carcinoma

Case report: ATIC-ALK fusion in infant-type hemispheric glioma and response to lorlatinib

Development and validation of an MRI-radiomics nomogram for the prognosis of pancreatic ductal adenocarcinoma

Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC

Global research trends in palliative care for breast cancer from 2012 to 2022: A scientometric analysis

The role of targeted therapy and immune therapy in the management of non-small cell lung cancer brain metastases

Editorial: Reviews in cancer genetics

Safety and feasibility of robotic-assisted thoracic surgery after neoadjuvant chemoimmunotherapy in non-small cell lung cancer

Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain

Pathogen-driven cancers from a structural perspective: Targeting host-pathogen protein-protein interactions

Benefits of switching from intravenous to subcutaneous daratumumab: Perspectives from UK healthcare providers

Vascular endothelial growth factor and risk of malignant brain tumor: A genetic correlation and two-sample Mendelian randomization study

Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis

Global scientific trends in laparoscopy and gastric cancer in the 21st century: A bibliometric and visual mapping analysis

A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer

Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene

Association between multiple coagulation-related factors and lymph node metastasis in patients with gastric cancer: A retrospective cohort study

CNS efficacy of afatinib as first-line treatment in advanced non-small cell lung cancer patients with EGFR mutations

Association of circulating tumor cells and IMP3 expression with metastasis of osteosarcoma

Investigating the impact of COVID-19 on patients with cancer from areas of conflict within the MENA region treated at King Hussein Cancer Center

Transarterial chemoembolization combined with lenvatinib versus transarterial chemoembolization combined with sorafenib for unresectable hepatocellular carcinoma: A systematic review and meta-analysis

Current understanding of cancer stem cells: Immune evasion and targeted immunotherapy in gastrointestinal malignancies

Developing mRNA signatures as a novel prognostic biomarker predicting high risk multiple myeloma

Artificial-intelligence-based computed tomography histogram analysis predicting tumor invasiveness of lung adenocarcinomas manifesting as radiological part-solid nodules

Geriatric assessment for older patients with breast cancer: A single-institution study

Global research trends between gut microbiota and lung cancer from 2011 to 2022: A bibliometric and visualization analysis

Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors

Nomogram prediction model of postoperative pneumonia in patients with lung cancer: A retrospective cohort study

Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors

Integrating copy number data of 64 iAMP21 BCP-ALL patients narrows the common region of amplification to 1.57 Mb

Targeted therapy for intractable cancer on the basis of molecular profiles: An open-label, phase II basket trial (Long March Pathway)

LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells

Association between metabolic obesity phenotypes and multiple myeloma hospitalization burden: A national retrospective study

Editorial: Women in breast cancer: 2021

Macrophage – tumor cell interaction beyond cytokines

Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis

Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases

Circulating immune index predicting the prognosis of patients with hepatocellular carcinoma treated with lenvatinib and immunotherapy

Novel considerations on EGFR-based therapy as a contributor to cancer cell death in NSCLC

Editorial: Critical complications in pediatric oncology and hematopoietic cell transplant – how far we have come and how much further we must go

Evolution and clinical significance of HER2-low status after neoadjuvant therapy for breast cancer

Editorial: Discovery of small molecule lead compounds: A driving force to unravel new anticancer targets and mechanisms

Humoral Effect of SARS-CoV-2 mRNA vaccination with booster dose in solid tumor patients with different anticancer treatments

Immunophenotypic measurable residual disease monitoring in adult acute lymphoblastic leukemia patients undergoing allogeneic hematopoietic stem cell transplantation

Comparison of the retroperitoneal laparoscopic adrenalectomy versus transperitoneal laparoscopic adrenalectomy for large (≥6cm) pheochromocytomas: A single-centre retrospective study

Breast cancer patient-derived explant cultures recapitulate in vivo drug responses

A potential link between aberrant expression of ECRG4 and atrial fibrillation

Iron metabolism in colorectal cancer

Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT

The evolving use of measurable residual disease in chronic lymphocytic leukemia clinical trials

PARP inhibitors in the treatment of ARID1A mutant ovarian clear cell cancer: PI3K/Akt1-dependent mechanism of synthetic lethality

Case report: PD-1 inhibitor-based treatment strategies in gastric cancer complicated by bone marrow metastasis and disseminated intravascular coagulation: A report of two cases

Association of regional anesthesia with oncological outcomes in patients receiving surgery for bladder cancer: A meta-analysis of observational studies

Case Report: The effective treatment of patients in advanced no-small cell lung cancer patients with EGFR G719X/S768I/L861Q and acquired MET amplification: A case series and literature review

Direct and indirect damage zone of radiofrequency ablation in porcine lumbar vertebra

Can cancer go green? It’s up to us

Editorial: Drug-resistance in cancer cells: A new wine in an old bottle

Multivariate analysis of prognostic factors in patients with lung cancer

Machine learning-based neddylation landscape indicates different prognosis and immune microenvironment in endometrial cancer

Comparing efficacy and safety of first-line treatment of metastatic renal cell carcinoma: A Bayesian network meta-regression analysis

The efficacies and biomarker investigations of antiangiogenic agents and PD-1 inhibitors for metastatic soft tissue sarcoma: A multicenter retrospective study

MRI-based pre-Radiomics and delta-Radiomics models accurately predict the post-treatment response of rectal adenocarcinoma to neoadjuvant chemoradiotherapy

Multiple primary lung cancer: Updates of clinical management and genomic features

Incorporating the synthetic CT image for improving the performance of deformable image registration between planning CT and cone-beam CT

The clinical and neurocognitive functional changes with awake brain mapping for gliomas invading eloquent areas: Institutional experience and the utility of The Montreal Cognitive Assessment

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

Healthcare coverage affects survival of EGFR-mutant Thai lung cancer patients

Comprehensive analysis of cuproptosis-related genes on bladder cancer prognosis, tumor microenvironment invasion, and drug sensitivity

Prophylactic inguinal lymphadenectomy for high-risk cN0 penile cancer: The optimal surgical timing

Primary retroperitoneal nodal endometrioid carcinoma associated with Lynch syndrome: A case report

Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application

Distinctive modulation of hepcidin in cancer and its therapeutic relevance

Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study

Editorial: Advanced imaging in breast cancer: New hopes, new horizons!

Clinical application of VATS combined with 3D-CTBA in anatomical basal segmentectomy

Patient-specific virtual three-dimensional surgical navigation for gastric cancer surgery: A prospective study for preoperative planning and intraoperative guidance

Efficacy of third-line anti-EGFR-based treatment versus regorafenib or trifluridine/tipiracil according to primary tumor site in RAS/BRAF wild-type metastatic colorectal cancer patients

Maximal safe resection of diffuse lower grade gliomas primarily within central lobe using cortical/subcortical direct electrical stimulation under awake craniotomy

The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation

Angiogenesis regulators S100A4, SPARC and SPP1 correlate with macrophage infiltration and are prognostic biomarkers in colon and rectal cancers

The road to breast cancer screening with diffusion MRI

Multiparametric magnetic resonance imaging-based radiomics nomogram for predicting tumor grade in endometrial cancer

Prognostic value of lipid profile in adult hemophagocytic lymphohistiocytosis

Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas

PMS2-associated Lynch syndrome: Past, present and future

Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy

Genome-wide identification of A-to-I RNA editing events provides the functional implications in PDAC

Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases

Corona enhancement combined with microvascular invasion for prognosis prediction of macrotrabecular-massive hepatocellular carcinoma subtype

The value of contrast-enhanced ultrasonography in differential diagnosis of primary testicular germ cell tumors and non-germ cell tumors over 50 years old

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis

Prognostic values of long noncoding RNA in bone metastasis of prostate cancer: A systematic review and meta-analysis

Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients

ARID1A in cancer: Friend or foe?

Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy: Retrospective multicenter study with different MRI scanners

Association between small nucleolar RNA host gene expression and survival outcome of colorectal cancer patients: A meta-analysis based on PRISMA and bioinformatics analysis

Flavin fluorescence lifetime and autofluorescence optical redox ratio for improved visualization and classification of brain tumors

Editorial: Improving quality of life in patients with differentiated thyroid cancer

A novel method of ultrasound-guided positive staining using indocyanine green fluorescence in laparoscopic anatomical liver resection of segments VII and VIII

Preoperative prediction of tumor deposits in rectal cancer with clinical-magnetic resonance deep learning-based radiomic models

Sacituzumab govitecan and radiotherapy in metastatic, triple-negative, and BRCA-mutant breast cancer patient with active brain metastases: A case report

Endoscopic surveillance of Lynch syndrome at a highly specialized center in Sweden: An observational study of interval colorectal cancer and individual risk factors

The associated risk of Blastocystis infection in cancer: A case control study

Intrathymic growing bronchogenic cyst mimicking thymoma: A case report

Development and validation of an ensemble machine-learning model for predicting early mortality among patients with bone metastases of hepatocellular carcinoma

Treatment options for patients with human epidermal growth factor 2-positive breast cancer brain metastases: A systematic review and meta-analysis

A common genetic variation in GZMB may associate with cancer risk in patients with Lynch syndrome

Correlation of serum IGF-1, AGEs and their receptors with the risk of colorectal cancer in patients with type 2 diabetes mellitus

Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7

Establishment and validation of nomogram model for the diagnosis of AFP-negative hepatocellular carcinoma

Emerging roles of endoplasmic reticulum stress in the cellular plasticity of cancer cells

Transverse prostate maximum sectional area can predict clinically significant prostate cancer in PI-RADS 3 lesions at multiparametric magnetic resonance imaging

FLT3-TKD in the prognosis of patients with acute myeloid leukemia: A meta-analysis

Multicolor flow cytometric assessment of Ki67 expression and its diagnostic value in mature B-cell neoplasms

MRI radiomics and potential applications to glioblastoma

Comparison of 68Ga-FAPI and 18F-FDG PET/CT for the diagnosis of primary and metastatic lesions in abdominal and pelvic malignancies: A systematic review and meta-analysis

Cancer-associated fibroblasts, and clinicopathological characteristics and prognosis of gastric cancer: A systematic review and meta-analysis

An overview of radiolabeled amino acid tracers in oncologic imaging

TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment

Editorial: The role of STAT3 signaling pathway in tumor progression

The efficacy and adverse effects of anlotinib in the treatment of high-grade glioma: A retrospective analysis

Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model

Case report: Genomic analysis of a therapy-related chronic myelomonocytic leukemia with KMT2A rearrangement that progressed to acute myeloid leukemia with acute promyelocytic leukemia-like features

Editorial: Plasticity of immune cells in tumor microenvironment

Case report: A case of rectal metastatic squamous cell carcinoma from the esophagus

Editorial: Imaging of bone cancers – novel methodologies and optimizations

Perioperative oncolytic virotherapy to counteract surgery-induced immunosuppression and improve outcomes in pancreatic ductal adenocarcinoma

The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel-mediated resistance in gastric cancer cell lines

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Quantitative analysis of artificial intelligence on liver cancer: A bibliometric analysis

The immunotherapy advancement targeting malignant blastomas in early childhood

Deep learning for automatic head and neck lymph node level delineation provides expert-level accuracy

Characterization of clonal immunoglobulin heavy V-D-J gene rearrangements in Chinese patients with chronic lymphocytic leukemia: Clinical features and molecular profiles

Case report: A rare case of thyrotropin-secreting pituitary macroadenoma with diffuse calcification presenting with hyperthyroidism and literature review

Artificial intelligence-based prediction of overall survival in metastatic renal cell carcinoma

Integrated clinical analysis and data mining assessed the impact of NOX4 on the immune microenvironment and prognosis of pancreatic cancer

Editorial: Local ablative therapies for the management of lung cancer

The progress in our understanding of CIN in breast cancer research

Sintilimab plus Lenvatinib conversion therapy for intermediate/locally advanced hepatocellular carcinoma: A phase 2 study

Effect of short-term prehabilitation of older patients with colorectal cancer: A propensity score-matched analysis

Identification and validation of a novel ubiquitination-related gene UBE2T in Ewing’s sarcoma

Post-transplant cyclophosphamide versus anti-thymocyte globulin in allogeneic hematopoietic stem cell transplantation from unrelated donors: A systematic review and meta-analysis

The effect of perioperative blood transfusion on survival after renal cell carcinoma nephrectomy: A systematic review and meta-analysis

Whole-genome sequencing identified novel mutations in a Chinese family with lynch syndrome

Immunotherapy associated central nervous system complications in primary brain tumors

Epigenetic reprogramming in pancreatic premalignancy and clinical implications

Organoid drug screening report for a non-small cell lung cancer patient with EGFR gene mutation negativity: A case report and review of the literature

Characteristics of recurrence, predictors for relapse and prognosis of rapid relapse triple-negative breast cancer

Nonfunctional ectopic adrenocortical carcinoma in the lung: A case report and literature review

Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma

Editorial: Advances in malignant pleural mesothelioma: Diagnosis, treatment, and molecular mechanisms

Recurrence risk stratification for locally advanced cervical cancer using multi-modality transformer network

Dosimetric comparison of robust angles in carbon-ion radiation therapy for prostate cancer

Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria

USP20 is a predictor of poor prognosis in colorectal cancer and associated with lymph node metastasis, immune infiltration and chemotherapy resistance

Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: A comprehensive meta-analysis

Recurrent glioblastoma metastatic to the lumbar vertebra: A case report and literature review: Surgical oncology

Applications of different machine learning approaches in prediction of breast cancer diagnosis delay

Unmanipulated haploidentical hematopoietic stem cell transplantation for pediatric de novo acute megakaryoblastic leukemia without Down syndrome in China: A single-center study

Breast cancer subtype and clinical characteristics in women from Peru

A novel RNA modification prognostic signature for predicting the characteristics of the tumor microenvironment in gastric cancer

Development of a nomogram to predict the risk of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis on antivirals

Unexpected curative effect of PD-1 inhibitor in gastric cancer with brain metastasis: A case report

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

The relationship between single nucleotide polymorphisms and skin cancer susceptibility: A systematic review and network meta-analysis

Development and validation of a nomogram to evaluate the therapeutic effects of second-line axitinib in patients with metastatic renal cell carcinoma

A diagnostic scoring model of ENKTCL in the nose-Waldeyer’s ring based on logistic regression: Differential diagnosis from DLBCL

Diagnostic value of tumor-associated autoantibodies panel in combination with traditional tumor markers for lung cancer

Lamivudine 24-month-long prophylaxis is a safe and efficient choice for the prevention of hepatitis B virus reactivation in HBsAg-negative/HBcAb-positive patients with advanced DLBCL undergoing upfront R-CHOP-21

Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

Which site is better for prophylactic ileostomy after laparoscopic rectal cancer surgery? By the specimen extraction site or new site: A systematic review and meta-analysis

Editorial: Cancer cell reprogramming: Impact on carcinogenesis and cancer progression

Editorial: Targeting cancer cell intracellular metabolism as a strategy against therapy resistance

Editorial: Recent advances in cervical cancer radiotherapy

Helicobacter pylori infection induces gastric precancerous lesions and persistent expression of Angpt2, Vegf-A and Tnf-A in a mouse model

Comparison of oncological outcomes in elderly early-stage cervical cancer patients treated with radical surgery or radiotherapy: A real-world retrospective study with propensity score matching

Application of nanomedicine in radiotherapy sensitization

A systematic analysis of the global and regional burden of colon and rectum cancer and the difference between early- and late-onset CRC from 1990 to 2019

Atypical ATMs: Broadening the phenotypic spectrum of ATM-associated hereditary cancer

Supportive care of neurodegenerative patients

UBE2S and UBE2C confer a poor prognosis to breast cancer via downregulation of Numb

Editorial: Epidemiological trends in hematological malignancies

Editorial: Exercise, physical therapy, and wellbeing in breast cancer patients

Plant-derived natural products and combination therapy in liver cancer

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

Common statistical concepts in the supervised Machine Learning arena

Efficacy and safety of treatment regimens for patients with metastatic, locally advanced, or recurrent breast cancer carrying BRCA1/BRCA2 pathogenic variants: A network meta-analysis

Editorial: Combining multiple non-invasive images and/or biochemical tests to predict prostate cancer aggressiveness

Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma

Convolutional neural network based on automatic segmentation of peritumoral shear-wave elastography images for predicting breast cancer

A comprehensive overview of the relationship between RET gene and tumor occurrence

Comprehensive genomic profiling: Does timing matter?

Validation of thermal dynamics during Hyperthermic IntraPEritoneal Chemotherapy simulations using a 3D-printed phantom

Case report: Response to endocrine therapy in triple-negative breast cancer metastases with altered hormone receptors

Ruxolitinib treatment in myelofibrosis and polycythemia vera causes suboptimal humoral immune response following standard and booster vaccination with BNT162b2 mRNA COVID-19 vaccine

Safety and rapid response of dabrafenib and trametinib therapy during hyperbilirubinemia in metastatic melanoma

Integrated multi-dimensional deep neural network model improves prognosis prediction of advanced NSCLC patients receiving bevacizumab

Measurable residual disease in chronic lymphocytic leukemia

Segmental chromosomal aberrations as the poor prognostic factor in children over 18 months with stage 3 neuroblastoma without MYCN amplification

The positive relationship between androgen receptor splice variant-7 expression and the risk of castration-resistant prostate cancer: A cumulative analysis

Corrigendum: Microscopic polyangiitis presenting with persistent cough and hemoptysis in pediatrics: A case report and review of the literature

Outcomes of beta blocker use in advanced hepatocellular carcinoma treated with immune checkpoint inhibitors

Review of biomarkers for response to immunotherapy in HNSCC microenvironment

Identification of TSGA10 and GGNBP2 splicing variants in 5′ untranslated region with distinct expression profiles in brain tumor samples

Efficacy and safety of a biomarker-driven cetuximab-based treatment regimen over 3 treatment lines in mCRC patients with RAS/BRAF wild type tumors at start of first line: The CAPRI 2 GOIM trial

Monoamine oxidase A: An emerging therapeutic target in prostate cancer

Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy

A molecular study of pediatric pilomyxoid and pilocytic astrocytomas: Genome-wide copy number screening, retrospective analysis of clinicopathological features and long-term clinical outcome

Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis

Positive response to niraparib in chemo-refractory patients with metastatic appendiceal mucinous adenocarcinoma harboring ATM mutations: A case report

Development of novel biliary metal stent with coil-spring structure and its application in vivo swine biliary stricture model

Metabolism-related signatures is correlated with poor prognosis and immune infiltration in hepatocellular carcinoma via multi-omics analysis and basic experiments

The emerging role of microtubules in invasion plasticity

Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials

[18F]FDG PET/CT versus [18F]FDG PET/MRI for the diagnosis of colorectal liver metastasis: A systematic review and meta-analysis

Prediction of CD3 T cells and CD8 T cells expression levels in non-small cell lung cancer based on radiomic features of CT images

Predicting survival of NSCLC patients treated with immune checkpoint inhibitors: Impact and timing of immune-related adverse events and prior tyrosine kinase inhibitor therapy

Endoscopic far-lateral supracerebellar infratentorial approach for resection of posterior clinoid meningioma: Case report and literature review

Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours: A prospective pilot study

A clinical prediction model for lung metastasis risk in osteosarcoma: A multicenter retrospective study

The cancer-risk variant frequency among Polish population reported by the first national whole-genome sequencing study

Sub-differentiation of PI-RADS 3 lesions in TZ by advanced diffusion-weighted imaging to aid the biopsy decision process

Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma

Editorial: Interdisciplinary surgical strategies for complex tumor defects in modern oncology

Autophagy-dependent ferroptosis as a potential treatment for glioblastoma

Blood-tumor barrier opening by MRI-guided transcranial focused ultrasound in a preclinical breast cancer brain metastasis model improves efficacy of combinatorial chemotherapy

FGFR inhibitors combined with nab-paclitaxel - A promising strategy to treat non-small cell lung cancer and overcome resistance

Leveraging intelligent optimization for automated, cardiac-sparing accelerated partial breast treatment planning

Knockout of ENO1 leads to metabolism reprogramming and tumor retardation in pancreatic cancer

99mTc-rituximab tracer injection for guiding internal mammary sentinel lymph nodes biopsy in primary breast cancer: A prospective observational study

Ultrasonographic manifestations and the effective diagnosis of epididymal leiomyosarcoma: Case report and systematic literature review

Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer

A novel ferroptosis-related gene signature for predicting prognosis in multiple myeloma

High GNG4 predicts adverse prognosis for osteosarcoma: Bioinformatics prediction and experimental verification

Surgical strategy of laparoscopic partial nephrectomy: It is more suitable to use transperitoneal approach in anterior tumor patients and retroperitoneal approach in posterior tumor patients

Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in surgically resected schwannomas

GA-OH enhances the cytotoxicity of photon and proton radiation in HPV+ HNSCC cells

In-depth circulating tumor DNA sequencing for prognostication and monitoring in natural killer/T-cell lymphomas

Evaluation of Lee–Carter model to breast cancer mortality prediction in China and Pakistan

Editorial: Targeting metabolism of cancer cells and host to overcome drug resistance: Preclinical and clinical studies

High-risk multiple myeloma predicted by circulating plasma cells and its genetic characteristics

Risk factors for post-transplant relapse and survival in younger adult patients with t(8;21)(q22;q22) acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: A multicenter retrospective study

Risk stratification of postoperative cardiopulmonary toxicity after trimodality therapy for esophageal cancer

Effectiveness, safety and pharmacokinetics of Polo-like kinase 1 inhibitors in tumor therapy: A systematic review and meta-analysis

Adjuvant effect of herbal medicine on transarterial chemoembolization in patients with hepatocellular carcinoma: A systematic review and meta-analysis

Atrophic dermatofibrosarcoma protuberans: Two case reports and literature review

Case report: Responses to the combination of gemcitabine with sirolimus in two patients with TSC-mutated sarcomas

Different pathological response and histological features following neoadjuvant chemotherapy or chemo-immunotherapy in resected non-small cell lung cancer

Targeted O-glycoproteomics for the development of diagnostic markers for advanced colorectal cancer

Application of enhanced recovery after surgery in partial nephrectomy for renal tumors: A systematic review and meta-analysis

Dynamic changes in PSA levels predict prognostic outcomes in prostate cancer patients undergoing androgen -deprivation therapy: A multicenter retrospective analysis

Preservation of the integrity of facial nerve in vestibular schwannoma microsurgery: A consecutive study of 127 clinical cases focusing on nervus intermedius

TOMM34 serves as a candidate therapeutic target associated with immune cell infiltration in colon cancer

Metabolomic biomarkers for the diagnosis and post-transplant outcomes of AFP negative hepatocellular carcinoma

Efficacy and safety of anti-PD-1 antibody plus chemoradiotherapy in locally advanced esophageal squamous cancer

A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database

Construction and validation of a novel nomogram to predict cancer-specific survival in patients with gastric adenocarcinoma

Prognostic significance of ING3 expression in patients with cancer: A systematic review and meta-analysis

Overexpressed Nup88 stabilized through interaction with Nup62 promotes NF-κB dependent pathways in cancer

A novel signature constructed by super-enhancer-related genes for the prediction of prognosis in hepatocellular carcinoma and associated with immune infiltration

Magnetic resonance findings of Stewart–Treves Syndrome in primary limb lymphedema compared with pathology: A retrospective single-center study

Case Report: Pancreatic metastasis of renal cell carcinoma 16 years after nephrectomy

Cuproptosis-related genes score: A predictor for hepatocellular carcinoma prognosis, immunotherapy efficacy, and metabolic reprogramming

Effective oxygen metabolism-based prognostic signature for colorectal cancer

Corrigendum: HER-2 positive primary neuroendocrine neoplasms of the breast with signet ring feature: A case report and review of literature

Opinion: What defines high-risk CLL in the post-chemoimmunotherapy era?

Editorial: Factors that impact the survival of non-small cell lung cancer

GPX3 expression was down-regulated but positively correlated with poor outcome in human cancers

A phase Ib study of interleukin-2 plus pembrolizumab for patients with advanced melanoma

PTCL, NOS: An update on classification, risk-stratification, and treatment

Mitochondrial gene expression signature predicts prognosis of pediatric acute myeloid leukemia patients

Neoadjuvant plus adjuvant combined or sequenced vemurafenib, cobimetinib and atezolizumab in patients with high-risk, resectable BRAF-mutated and wild-type melanoma: NEO-TIM, a phase II randomized non-comparative study

Effect of EGFR-TKIs combined with craniocerebral radiotherapy on the prognosis of EGFR-mutant lung adenocarcinoma patients with brain metastasis: A propensity-score matched analysis

Learning curve analysis of single-port thoracoscopic combined subsegmental resections

CD203c is expressed by human fetal hepatoblasts and distinguishes subsets of hepatoblastoma

Marked paper: Type 2 diabetes mellitus indicates increased postoperative complications and poor prognosis in colorectal cancer patients receiving curative surgery

Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells

The prognostic value and response to immunotherapy of immunogenic cell death-associated genes in breast cancer

Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry

RNF6 activates TGF-β1/c-Myb pathway to promote EMT in esophageal squamous cell carcinoma

Cancer treatment data available in European cancer registries: Where are we and where are we going?

A prognostic NAD+ metabolism-related gene signature for predicting response to immune checkpoint inhibitor in glioma

Differences in the immunoglobulin gene repertoires of IgG versus IgA multiple myeloma allude to distinct immunopathogenetic trajectories

Small hyperattenuating adrenal nodules in patients with lung cancer: Differentiation of metastases from adenomas on biphasic contrast-enhanced computed tomography

Deep learning-based morphological feature analysis and the prognostic association study in colon adenocarcinoma histopathological images

Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors

Tyrosine kinases in nodal peripheral T-cell lymphomas

Hemophagocytic lymphohistiocytosis in gastric cancer: A rare syndrome for the oncologist. Case report and brief review

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Editorial: Single cell meets metabolism and cancer biology

Risk factors for postoperative myasthenia gravis in patients with thymoma without myasthenia gravis: A systematic review and meta-analysis

CXCL9 correlates with antitumor immunity and is predictive of a favorable prognosis in uterine corpus endometrial carcinoma

The feasibility of decreasing the thresholds for biopsy in Kwak and C TIRADSs

Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

Deep learning-based algorithm improves radiologists’ performance in lung cancer bone metastases detection on computed tomography

Immunotherapy progress and clinical strategy of unresectable locally advanced non-small cell lung cancer

Multi-channel GAN–based calibration-free diffusion-weighted liver imaging with simultaneous coil sensitivity estimation and reconstruction

Evaluation of KRASG12C inhibitor responses in novel murine KRASG12C lung cancer cell line models

Latest evidence of microwave ablation for papillary thyroid microcarcinoma compared with surgery: A systematic review and meta-analysis

A bibliometric and visual analysis of publications on artificial intelligence in colorectal cancer (2002-2022)

Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge

A nomogram based on LI-RADS features, clinical indicators and quantitative contrast-enhanced MRI parameters for predicting glypican-3 expression in hepatocellular carcinoma

Editorial: Case reports in urothelial cancer

Effectiveness and safety of pembrolizumab for patients with advanced non-small cell lung cancer in real-world studies and randomized controlled trials: A systematic review and meta-analysis

The research landscape of the quality of life or psychological impact on gynecological cancer patients: A bibliometric analysis

Editorial: Imaging in non-small cell lung cancer

Comparison of diagnostic and treatment processes among pediatric and adolescents and young adults’ populations suffering from acute lymphoblastic leukemia and lymphomas

Gastric cancer clinical characteristics and their altered trends in South China: An epidemiological study with 2,800 cases spanning 26 years

Hepatitis B virus-infection related cryoglobulinemic vasculitis. Clinical manifestations and the effect of antiviral therapy: A review of the literature

Corrigendum: Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

Primary spinal anaplastic ependymoma: A single-institute retrospective cohort and systematic review

Sellar B lymphoblastic lymphoma mimics pituitary apoplexy with newly discovered gene mutations in TP53 and PAX5: A case report

Research progress on molecular biomarkers of acute myeloid leukemia

Clinical, pathological, and radiological features of 80 pediatric diffuse intrinsic pontine gliomas: A single-institute study

Pharyngoesophageal diverticulum mimicking thyroid nodules: Some interesting ultrasonographic signs

Agents contributing to secondary immunodeficiency development in patients with multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin lymphoma: A systematic literature review

Genetic variants in the calcium signaling pathway participate in the pathogenesis of colorectal cancer through the tumor microenvironment

Volume change rate before and after neoadjuvant systemic therapy of breast cancer is an efficacious evaluation index to predict pathological complete response

Pharmacokinetics of single- and multiple-dose flumatinib in patients with chronic phase chronic myeloid leukemia

Dynamic radiomics for predicting the efficacy of antiangiogenic therapy in colorectal liver metastases

Self-attention random forest for breast cancer image classification

Adverse reactions after treatment with dasatinib in chronic myeloid leukemia: Characteristics, potential mechanisms, and clinical management strategies

Commentary: Cancer-testis antigen lactate dehydrogenase C4 as a novel biomarker of male infertility and cancer

Transcription factor E2F8 is a therapeutic target in the basal-like subtype of breast cancer

A novel Cuprotosis-related signature predicts the prognosis and selects personal treatments for melanoma based on bioinformatics analysis

Heterogeneous disease and intermittent treatment in metastatic colorectal cancer: A case report

The emerging applications and advancements of Raman spectroscopy in pediatric cancers

Myeloid leukemia factor 1: A “double-edged sword” in health and disease

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Efficacy and survival analysis of nimotuzumab combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma

A new intronic quantitative PCR method led to the discovery of transformation from human ascites to murine malignancy in a mouse model

Dinutuximab beta combined with chemotherapy in patients with relapsed or refractory neuroblastoma

The prognostic predictive value of systemic immune index and systemic inflammatory response index in nasopharyngeal carcinoma: A systematic review and meta-analysis

Population-based temporal trends and ethnic disparity in breast cancer mortality in South Africa (1999-2018): Joinpoint and age–period–cohort regression analyses

Prediction of microvascular invasion in hepatocellular carcinoma based on preoperative Gd-EOB-DTPA-enhanced MRI: Comparison of predictive performance among 2D, 2D-expansion and 3D deep learning models

Preliminary study on CT contrast-enhanced radiomics for predicting central cervical lymph node status in patients with thyroid nodules

The role of immunotherapy in non-clear cell renal cell carcinoma

MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma

Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer

Sex-specific radiomic features of L-[S-methyl-11C] methionine PET in patients with newly-diagnosed gliomas in relation to IDH1 predictability

Preoperative individual-target transcranial magnetic stimulation demonstrates an effect comparable to intraoperative direct electrical stimulation in language-eloquent glioma mapping and improves postsurgical outcome: A retrospective fiber-tracking and electromagnetic simulation study

Hepatoid adenocarcinoma of the stomach: CT findings

Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion

The value of enhanced CT features and texture-signatures in assessing the inflammatory infiltration of pancreatic ductal adenocarcinoma

Clinical and pathological heterogeneity of four common fusion subtypes in Xp11.2 translocation renal cell carcinoma

Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period

Case Report: Defect repair post-resection of cervical tracheal granular cell tumor by cervical anterior banded myofascial flap: A case study and literature review

An integrated solution of deep reinforcement learning for automatic IMRT treatment planning in non-small-cell lung cancer

Double osseous flaps for simultaneous midfacial and mandible reconstruction: Automation in surgical complexity within an entirely computerized workflow

Bibliometric study on the knowledge graph of immunotherapy for head and neck cancer

Case report: Application of morphology in the diagnosis of siderosis in a patient with tuberculosis infection

Advances in immune checkpoint inhibitor combination strategies for microsatellite stable colorectal cancer

The findings on the CEUS of diffuse large B cell lymphoma in abdomen: A case report and literature review

Targeting immune-onco-metabolism for precision cancer therapy

A radiomic biomarker for prognosis of resected colorectal cancer liver metastases generalizes across MRI contrast agents

Case report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic submucosal dissection

Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1

Clinical advancement of precision theranostics in prostate cancer

Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient

Interim result of phase II, prospective, single-arm trial of long-course chemoradiotherapy combined with concurrent tislelizumab in locally advanced rectal cancer

Low expression of HIF1AN accompanied by less immune infiltration is associated with poor prognosis in breast cancer

Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

Chemo-immunotherapy for metastatic non-squamous NSCLC in a patient with HIV infection: A case report

Multiple ectopic recurrent germ cell tumors after total pineal mature teratoma removal: A case report and literature review

Effects of plasma-derived exosomes from the normal and thin Bactrian camels on hepatocellular carcinoma and their differences at transcriptome and proteomics levels

The level of kinesiophobia in breast cancer women undergoing surgical treatment

PKCδ promotes the invasion and migration of colorectal cancer through c-myc/NDRG1 pathway

Gadoxetic acid–enhanced MRI with a focus on LI-RADS v2018 imaging features predicts the prognosis after radiofrequency ablation in small hepatocellular carcinoma

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?

Modified anterior approach preserving Retzius space versus standard anterior approach robot-assisted radical prostatectomy: A matched-pair analysis

Case Report: Disease progression of renal cell carcinoma containing a novel putative pathogenic KAT6A::NRG1 fusion on Ipilimumab- Nivolumab immunotherapy. A case study and review of the literature

Geriatric assessment in the older adult with genitourinary cancer: A narrative review

Tumor−associated macrophage polarization in the inflammatory tumor microenvironment

Prognostic biomarker NEIL3 and its association with immune infiltration in renal clear cell carcinoma

Primary hepatic angiosarcoma with noncirrhotic portal hypertension: A case report

Clinicopathologic characteristics and prognostic significance of HER2-low expression in patients with early breast cancer: A systematic review and meta-analysis

Distinct respiratory microbiota associates with lung cancer clinicopathological characteristics

Highly expressed CENPL is correlated with breast cancer cell proliferation and immune infiltration

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia

Construction of a DDR-related signature for predicting of prognosis in metastatic colorectal carcinoma

Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry

Editorial: Molecular and immune influences in the progression of gliomas

Prognostic and immunological role of sulfatide-related lncRNAs in hepatocellular carcinoma

Analysis of prognostic factors and construction of prognostic models for triple-positive breast cancer

T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations

A nomogram and risk classification system forecasting the cancer-specific survival of lymph- node- positive rectal cancer patient after radical proctectomy

Spatially resolved transcriptomics revealed local invasion-related genes in colorectal cancer

Renal cell carcinoma with intracardiac tumor thrombus extension: Radical surgery yields 2 years of postoperative survival in a single-center study over a period of 30 years

Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death

Endoscopic transcranial transdiaphragmatic approach in a single-stage surgery for giant pituitary adenomas

Editorial: Angiogenesis blockade for the treatment of gastrointestinal cancer

Minimally invasive sleeve lobectomy for centrally located lung cancer: A real-world study with propensity-score matching

Guidance for clinicians and patients with non-small cell lung cancer in the time of precision medicine

Evaluation of corrective effect of 6 degree of freedom couch on setup errors in intensity modulated radiotherapy for postoperative rectal cancer patients

Combination of ultrafast dynamic contrast-enhanced MRI-based radiomics and artificial neural network in assessing BI-RADS 4 breast lesions: Potential to avoid unnecessary biopsies

Factors associated with the use of adjuvant radiation therapy in stage III melanoma

Unexpected breast cancer mimicking benign lesions on ultrasound-guided vacuum-assisted excision biopsy: A retrospective cross-sectional study over a 20-year period

How to position the patient? A meta-analysis of positioning in vestibular schwannoma surgery via the retrosigmoid approach

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Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death

Content Provider	frontiers
Author	Shah, Harshit Stankov, Metodi Panayotova-Dimitrova, Diana Yazdi, Amir Budida, Ramachandramouli Klusmann, Jan-Henning Behrens, Georg M. N.
Description	Current cancer research has led to a renewed interest in exploring lysosomal membrane permeabilization and lysosomal cell death as an targeted therapeutic approach for cancer treatment. Evidence suggests that differences in lysosomal biogenesis between cancer and normal cells might open a therapeutic window. Lysosomal membrane stability may be affected by the so-called ‘busy lysosomal behaviour’ characterized by higher lysosomal abundance and activity and more intensive fusion or interaction with other vacuole compartments. Using a panel of multiple myeloid leukemia (ML) cell lines as well as leukemic patient samples, we demonstrated several-fold higher constitutive autolysosomal activity in ML cells as compared to human CD34+ hematopoietic cells. Importantly, we identified mefloquine as a selective activator of ML cells lysosomal biogenesis, which induced a sizable increase in ML lysosomal mass, acidity as well as cathepsin B and L activity. Concomitant mTOR inhibition synergistically increased lysosomal activity and autolysosomal fusion and simultaneously decreased the levels of key lysosomal stabilizing proteins, such as LAMP-1 and 2. As a consequence, mefloquine treatment combined with mTOR inhibition synergistically induced targeted ML cell death without additional toxicity. Taken together, these data provide a molecular mechanism and thus a rationale for a therapeutic approach for specific targeting of ML lysosomes.
Abstract	IntroductionCurrent cancer research has led to a renewed interest in exploring lysosomal membrane permeabilization and lysosomal cell death as a targeted therapeutic approach for cancer treatment. Evidence suggests that differences in lysosomal biogenesis between cancer and normal cells might open a therapeutic window. Lysosomal membrane stability may be affected by the so-called ‘busy lysosomal behaviour’ characterized by higher lysosomal abundance and activity and more intensive fusion or interaction with other vacuole compartments.MethodsWe used a panel of multiple myeloid leukemia (ML) cell lines as well as leukemic patient samples and updated methodology to study auto-lysosomal compartment, lysosomal membrane permeabilization and lysosomal cell death.ResultsOur analyses demonstrated several-fold higher constitutive autolysosomal activity in ML cells as compared to human CD34+ hematopoietic cells. Importantly, we identified mefloquine as a selective activator of ML cells' lysosomal biogenesis, which induced a sizeable increase in ML lysosomal mass, acidity as well as cathepsin B and L activity. Concomitant mTOR inhibition synergistically increased lysosomal activity and autolysosomal fusion and simultaneously decreased the levels of key lysosomal stabilizing proteins, such as LAMP-1 and 2.DiscussionIn conclusion, mefloquine treatment combined with mTOR inhibition synergistically induced targeted ML cell death without additional toxicity. Taken together, these data prov...
ISSN	2234943X
DOI	10.3389/fonc.2023.999738
Volume Number	13
Journal	Frontiers in Oncology
Language	English
Publisher Date	2023-02-01
Access Restriction	Open
Subject Keyword	Myeloid leukemia Lysosomal cell death Lysosomal membrane permeabilization Cancer treatment Mefloquine and autophagy
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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