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| Content Provider | frontiers |
|---|---|
| Author | Qin, Ruoyan Qian, Jie Shan, Mengjun Ruan, Guangxin Yang, Xiaofeng Wang, Yanwen Liu, Lingshuang |
| Abstract | Triple-negative breast cancer refers to breast cancer patients with negative estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Metastatic triple-negative breast cancer is predominantly treated with chemotherapy, but later-line treatment remains challenging. Breast cancer is highly heterogeneous, and the expression of hormone receptors is often inconsistent between primary and metastatic lesions. Here, we report a case of triple-negative breast cancer 17 years after surgery with lung metastases for 5 years that progressed to pleural metastases after multiple lines of chemotherapy. The pleural pathology suggested ER (+) and PR (+) and transformation to luminal A breast cancer. This patient received fifth-line letrozole endocrine therapy and achieved partial response (PR). The patient’s cough and chest tightness improved after treatment, associated tumor markers decreased, and progression-free survival (PFS) exceeded 10 months. Our results may be of clinical relevance for patients with hormone receptor alterations in advanced triple-negative breast cancer and suggest that individualized regimens should be developed for breast cancer based on the molecular expression of tumor tissue at the primary and metastatic sites. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2023.1023787 |
| Volume Number | 13 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2023-02-14 |
| Access Restriction | Open |
| Subject Keyword | Later-line treatment Metastases Altered hormone receptors Endocrine therapy Triple-negative breast cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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