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| Content Provider | frontiers |
|---|---|
| Author | Chen, Zhaoyi Jiang, Tongfei Yin, Xuejiao Li, Bin Tan, Zhongjian Guo, Jing |
| Abstract | Background: Insomnia disorder (ID) seriously affects the quality of people’s daily life, and acupuncture is an effective therapy for it. As an essential component of the upward activation system, the locus coeruleus (LC) plays a crucial role in sleep-wake regulation, its aberrant functional connectivity (FC) is found to be involved in ID. The purpose of this study was to explore the modulation effect of acupuncture on the resting state FC of LC in ID patients. Methods: 60 ID patients were recruited and randomly assigned to real acupuncture (RA) or sham acupuncture (SA) treatment. Resting-state functional magnetic resonance imaging (fMRI) data were collected before and after the treatment. With LC as the region of interest, the FC method was adopted to examine acupuncture-related modulation of intrinsic connectivity in ID patients. The Pittsburgh Sleep Quality Index (PSQI), Hyperarousal Scale (HAS), and actigraphy were used to assess sleep quality and cortical hyperarousal states. Associations between clinical outcomes and FC features were calculated using Pearson’s correlation analysis. Results: The improvement in sleep quality and hyperarousal in the RA group was greater than that in the SA group. After treatment, the FC between the LC and left inferior frontal gyrus (IFG) decreased in the RA group. The FC between the LC and left insula and supramarginal gyrus (SMG) was higher in the RA group. The change of LC FC values with the SMG was negatively associated with the change in PSQI scores. Conclusion: Acupuncture can modulate FC between the LC and IFG, insular gyrus, and SMG. This may imply the potential mechanism of acupuncture treatment for insomnia. |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2023.1131916 |
| Volume Number | 17 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2023-04-20 |
| Access Restriction | Open |
| Subject Keyword | Insomnia disorder Neuroimaging FMRI Locus Coeruleus Resting-state functional connectivity Acupuncture |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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