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| Content Provider | frontiers |
|---|---|
| Author | Wu, Shanshan Fan, Jiali Tang, Fajuan Chen, Lin Zhang, Xiaoyan Xiao, Dongqiong Li, Xihong |
| Abstract | There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release. The cytomatrix in the active zone (CAZ) is made up of proteins such as the regulating synaptic membrane exocytosis protein (RIM), RIM-binding proteins (RIM-BPs), ELKS/CAST, Bassoon/Piccolo, Liprin-α, and Munc13-1. RIM is a scaffold protein that interacts with CAZ proteins and presynaptic functional components to affect the docking, priming, and fusion of SVs. RIM is believed to plays an important role in regulating the release of neurotransmitters (NTs). In addition, abnormal expression of RIM has been detected in many diseases, such as retinal diseases, Asperger's syndrome (AS), and degenerative scoliosis. Therefore, we believe that studying the molecular structure of RIM and its role in neurotransmitter release will help to clarify the molecular mechanism of neurotransmitter release and identify targets for the diagnosis and treatment of the aforementioned diseases. |
| ISSN | 1662453X |
| DOI | 10.3389/fnins.2023.1123561 |
| Volume Number | 17 |
| Journal | Frontiers in Neuroscience |
| Language | English |
| Publisher Date | 2023-04-26 |
| Access Restriction | Open |
| Subject Keyword | RIM, Regulating synaptic membrane exocytosis CAZ, Cytomatrix in the active zone Synaptic Vesicles Neurotransmitter release SNARE Soluble Nethylmaleimide-sensitive factor attachment protein receptor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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