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| Content Provider | frontiers |
|---|---|
| Author | Sitlinger, Andrea Deal, Michael A. Garcia, Erwin Connelly, Margery Thompson, Dana Stewart, Tiffany Macdonald, Grace Hanson, Erik D. Neely, Megan Neely, Ben Artese, Ashley Weinberg, J. Brice Brander, Danielle Bartlett, David B. |
| Abstract | Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients with CLL. In univariate analyses of clinical factors, a longer time since diagnosis was associated with a higher likelihood of dysfunctional aerobic fitness (OR=3.56, 95% CI: 1.37–9.22; p=0.002) and physical performance (SPPB: OR=2.03, 95% CI: 1.20–3.44; p=0.004). Having received treatment was associated with a higher likelihood of dysfunctional aerobic fitness (OR=1.57, 95% CI: 1.02–2.40; p=0.036), SPPB (OR=1.85, 95% CI: 1.13–3.03; p=0.011) and grip strength (OR=1.67, 95% CI: 1.10–2.55; p=0.015). We found several small HDL particle parameters, higher levels of citrate (OR=2.01, 95% CI: 1.22–3.31; p=0.030) and lower levels of hemoglobin (OR=0.50, 95% CI: 0.31–0.82; p=0.030) were associated with a higher likelihood of dysfunctional aerobic fitness. Multivariable LASSO-penalised regression analyses using variable importance measures (VIM) showed that 7.8nm HDL particles (VIM=1.000) and total HDL particle levels (VIM=1.000) were more informative than clinical measures for the odds of dysfunctional aerobic fitness and 6-minute walk functional fitness, respectively while 10.3nm HDL particles (VIM=0.383) were more informative for grip strength. Time since diagnosis (VIM=0.680) and having received treatment (VIM=0.490) were more informative than lipoprotein measures for the odds of having dysfunctional SPPB. Taken together, we establish significant relationships between clinical, metabolic factors and physical characteristics that might prompt early use of ancillary support services. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2022.933619 |
| Volume Number | 12 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2022-08-03 |
| Access Restriction | Open |
| Subject Keyword | Chronic lymphocytic leukemia (CLL) Lipids and lipoproteins Metabolsim Physical Fitness Physical function |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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