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| Content Provider | frontiers |
|---|---|
| Author | Chen, Qi-Feng Li, Wang Yu, Simon Chun-ho Chou, Yi-Hong Rhim, Hyunchul Yang, Xiaoming Shen, Lujun Dong, Annan Huang, Tao Huang, Jinhua Zhang, Fujun Fan, Weijun Zhao, Ming Gu, Yangkui Huang, Zhimei Zuo, Mengxuan Zhai, Bo Xiao, Yueyong Kuang, Ming Li, Jiaping Han, Jianjun Song, Wei Ma, Jie Wu, Peihong |
| Abstract | In China, the majority of patients with hepatocellular carcinoma (HCC) result from long-term infection of hepatitis B. Pathologically, HCC is characterized by rich blood supply, multicentric origins, early vascular invasion and intrahepatic metastasis. Therefore, HCC is not a local disease but a systemic disease at the beginning of its occurrence. For this reason, a comprehensive treatment strategy should be adopted in the management of HCC, including local treatments (such as surgical resection, radiofrequency ablation, microwave ablation, chemical ablation and cryoablation, etc.), organ-level treatments (such as transcatheter arterial infusion of chemotherapy and transcatheter arterial chemoembolization [TACE]), and systemic treatments (such as immunotherapy, antiviral therapy and molecular targeted therapy, etc.). This consensus sets forth the minimally-invasive and multidisciplinary comprehensive guideline of HCC, focusing on the following eight aspects: (1) find the intrahepatic lesion and make precise staging; (2) TACE combined with ablation or ablation as the first choice of treatment for early stage or small HCC; (3) infiltrating HCC should be regarded as an independent subtype of HCC; (4) minimally-invasive comprehensive treatment could be adopted in treating metastatic lymph nodes; (5) multi-level subdivision of M-staging should be used for individualized treatment and predicting prognosis; (6) HCC with severe hepatic decompensation is the only candidate criterion for liver transplantation; (7) bio-immunotherapy, traditional Chinese medicine therapy, antiviral therapy, and psychosocial and psychopharmacological interventions should be advocated through the whole course of HCC treatment; (8) implementation of multicenter randomized controlled trials of minimally-invasive therapy versus surgery for early and intermediate stage HCC is recommended. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2021.621834 |
| Volume Number | 11 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2021-07-02 |
| Access Restriction | Open |
| Subject Keyword | Minimally-invasive therapy Multidisciplinary comprehensive treatment Consensus Guangzhou recommendations Hepatocellular Carcinoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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