Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus - Eastern Hepatobiliary Surgical Hospital consensus statement.

Content Provider	Europe PMC
Author	Cheng, Shuqun Yang, Jiamei Shen, Feng Zhou, Weiping Wang, Yi Cong, Wenming Yang, Guang shun Cheng, Hongyan Hu, Heping Gao, Chunfang Guo, Jia Li, Aijun Meng, Yan Jiang, Xiaoqing Yang, Yefa Qian, Guojun Luo, Ming Hu, Bing Man, Xiaobo Zhang, Baohua Su, Changqing Zhou, Feiguo Li, Nan Shi, Jie Wang, Meng Zheng, Yaxin Guo, Weixing Sun, Juxian Wang, Hongyang Lau, Wan-yee Wu, Meng-chao
Copyright Year	2016
Abstract	Hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) is associated with poor prognosis, early recurrence of HCC, and limited treatment options. Current guidelines do not have standardized diagnostic and treatment modalities, thus creating a need for a multidisciplinary treatment model for standardization of the treatment. Eastern Hepatobiliary Surgical Hospital (China) convened two working parties of experts from all the departments, to consolidate the current evidence, prevailing vision for the future, and experience of the practicing clinicians engaged in HCC management, so as to develop a consensus for PVTT diagnosis and treatment according to the GRADE system. Based on the quality of the existing evidence and the strength of recommendations, the consensus statements were categorized into 3 evidence levels (A/B/C) and 5 classes (I/II/IIa/IIb/III). The panel discussed and provided clarity on the management and research options in the field of HCC with PVTT. In addition, the panel also assessed the quality of the cited studies and assigned grades to the recommendation statements. Among the group of experts, there was excellent agreement with regard to effective diagnosis and treatment of HCC with PVTT. The recommendations of this consensus will provide guidance to physicians and clinical researchers on the effective management of HCC with PVTT.
Journal	Oncotarget
Volume Number	7
PubMed Central reference number	PMC5130047
Issue Number	26
PubMed reference number	27027235
e-ISSN	19492553
DOI	10.18632/oncotarget.8386
Language	English
Publisher	Impact Journals LLC
Publisher Date	2016-06-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2016 Cheng et al.
Subject Keyword	hepatocellular carcinoma portal vein tumor thrombus consensus multidisciplinary treatment recommendations
Content Type	Text
Resource Type	Article
Subject	Oncology