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| Content Provider | frontiers |
|---|---|
| Author | Maiuri, Francesco Mariniello, Giuseppe de Divitiis, Oreste Esposito, Felice Guadagno, Elia Teodonno, Giuseppe Barbato, Marcello Del Basso De Caro, Marialaura |
| Description | Abstract Background: The progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence and pattern of regrowth has scarcely been discussed. Methods: A surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low ( 5 years (p=0.036). Conclusion: The higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance. |
| Abstract | BackgroundThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed.MethodsA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (<15%); 2. moderately low (16–50%); 3. moderately high (51–79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence.ResultsThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (p < 0.0001). Meningiomas which recurred showed at initial surgery higher rates of low or moderately low PR expression than the non-recurrent ones (p = 0.0004), whereas the pattern of regrowth was not significant. Higher rates of PR values ≥80% were found in cases with time to recurrence >5 years (p = 0.036).ConclusionThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and po... |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2021.611218 |
| Volume Number | 11 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2021-07-15 |
| Access Restriction | Open |
| Subject Keyword | Proliferation index (MIB-1) Meningiomas Ki67 (MIB-1) Meningioma Recurrence WHO grade Progesterone Receptor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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