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[Advances in enrichment of phosphorylated peptides and glycopeptides by smart polymer-based materials].

Content Provider	Europe PMC
Author	ZHENG, Xintong WANG, Xue ZHANG, Fusheng ZHANG, Xuyang ZHAO, Yanyan QING, Guangyan
Copyright Year	2021
Abstract	翻译后修饰是蛋白质组学研究的前沿和重点,它不仅调节着蛋白质的折叠、状态、活性、定位以及蛋白质间的相互作用,也能帮助科学家更全面地了解生物体的生命过程,为疾病的预测、诊断和治疗提供更加强大的支撑和依据。翻译后修饰产物(例如磷酸化肽和糖肽)丰度很低,且存在着强烈的背景干扰,很难直接用质谱进行分析,因此迫切需要开发高效的富集材料和技术来选择性富集翻译后修饰产物。近年来,智能聚合物基材料通过外部物理、化学或生物刺激可逆地改变其结构和功能,实现对磷酸化肽和糖肽高度可控的吸附和脱附,进而衍生开发出一系列新颖的富集方法,极大地吸引研究者们的兴趣。一方面,智能聚合物基材料的响应变化包括材料疏水性的增加或减少、形状和形貌的改变、表面电荷的重新分布以及亲和配体的暴露或隐藏等特性。这些特性使得目标物和智能聚合物基材料之间的亲和力可以通过简单改变外部条件(如温度、pH值、溶剂极性和生物分子等)实现更可控和更智能的精细调节。另一方面,智能聚合物基材料为集成功能模块提供了便捷的可扩展平台,例如特定的识别组件,显著提高了目标物质的分离选择性。智能聚合物基材料在分离方面展现出巨大的潜力,这为蛋白质翻译后修饰产物的分析和研究带来了希望。围绕上述主题,该文依据Web of Science近20年来近50篇代表性文献,概述了智能聚合物基材料在磷酸化肽和糖肽分离及富集中的发展方向。
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9274847&blobtype=pdf
ISSN	10008713
Journal	Chinese Journal of Chromatography [Se Pu]
Volume Number	39
PubMed Central reference number	PMC9274847
Issue Number	1
PubMed reference number	34227355
DOI	10.3724/sp.j.1123.2020.05036
Language	English
Publisher	Editorial board of Chinese Journal of Chromatography
Publisher Date	2021-01-01
Publisher Place	No. 457, Zhongshan Road, Shahekou District, Dalian City, Liaoning Province(116023)
Access Restriction	Open
Rights License	本文是开放获取文章，遵循CC BY 4.0协议
Subject Keyword	蛋白质组学富集翻译后修饰智能聚合物磷酸化肽糖肽综述 proteomics enrichment post-translational modification (PTM) smart polymer phosphorylated peptides glycopeptides review
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Chemical Engineering Electrochemistry

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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