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Clinical and Virological Features of Acute Hepatic Exacerbations in Patients With Chronic Hepatitis B Virus Infection.
| Content Provider | Europe PMC |
|---|---|
| Author | Bestas, Remzi Yalcin, Kendal |
| Editor | Muacevic, Alexander Adler, John R |
| Copyright Year | 2021 |
| Abstract | Background and aimIn this study, we aimed to perform a comprehensive analysis of patients with acute hepatic flares observed during the course of chronic hepatitis B infection in order to provide early diagnosis, management, and best characterization of this unique group of hepatitis B patients.Patients and methodsThe study was designed in a retrospective and prospective manner. Chronic hepatitis B patients with acute hepatic flares, admitted to the Department of Gastroenterology and Hepatology were enrolled in the study. Demographic, clinical, biochemical, and virological findings were recorded via pre-prepared forms.ResultsThe study was conducted on 125 patients. The mean age was 34.08 ± 12.68 and the male to female ratio was determined as 2.28. Over 117 patients (93.6%) had at least one symptom. The most common symptoms and signs were fatigue (81.6%), anorexia (64%), jaundice (60%), and nausea (52%). Anti-HBc immunoglobulin M (IgM) antibody was detected in 24 patients (19.2%) and serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) was positive in 107 (85.6%) patients. The most common cause of exacerbations was spontaneous hepatic flares (80.8%).ConclusionAccording to the results of this single-center study, acute hepatic exacerbations are more common in young men. The disease usually presents with non-specific symptoms and jaundice is the most common finding. As a sign of intensive inflammation and hepatocellular injury, serum ferritin levels seem to be high. Serum HBV DNA and anti-HBc IgM positivity with elevated alpha-fetoprotein (AFP) levels are presenting features of acute hepatic exacerbations. |
| Journal | Cureus |
| Volume Number | 13 |
| DOI | 10.7759/cureus.15937 |
| PubMed Central reference number | PMC8234814 |
| Issue Number | 6 |
| PubMed reference number | 34194888 |
| e-ISSN | 21688184 |
| Language | English |
| Publisher | Cureus |
| Publisher Date | 2021-06-26 |
| Publisher Place | Palo Alto (CA) |
| Access Restriction | Open |
| Subject Keyword | chronic hepatitis b infection hepatic exacerbation hepatitis b virus flare clinic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
