Prognostic value of chronic hepatitis B virus infection in patients with breast cancer in a hepatitis B virus endemic area.

Content Provider	Europe PMC
Author	Xiao, Weikai Zhou, Ying Yu, Ping Yang, Anli Zheng, Shaoquan Tang, Hailin Xie, Xiaoming
Copyright Year	2020
Abstract	BackgroundExcept for hepatocellular carcinoma, chronic hepatitis B virus (HBV) infection has also been reported to be associated with increased morbidity and mortality of other cancers. However, the impact of chronic HBV infection on the prognosis of breast cancer (BC) remains unclear. Our study aimed to evaluate the prognostic value of HBV infection for BC in an endemic area of HBV in China.MethodsThere was a total of 1,904 patients with early BC who underwent mastectomy or breast-conserving surgery enrolled in our study. HBV infection on overall survival (OS) and hepatic metastasis-free survival (HMFS) was the main research indicator for this study.ResultsA total of 212 patients (11.1%) were identified with chronic HBV infection due to serum hepatitis B surface antigen (HBsAg) positive. HBsAg-positive patients had inferior OS (84.9% vs. 90.4%, P=0.005) and HMFS (92.5% vs. 97.1%, P=0.016) at 5 years than HBsAg-negative patients. Chronic HBV infection was an independent predictor of poor OS in patients with BC [multivariate analysis; hazard ratio (HR), 1.52; P=0.038], but not for HMFS. Subgroup analysis showed that chronic HBV infection was an unfavorable independent prognostic factor for OS in patients with stage II/III BC (HR, 1.59; P=0.025). The 5-year OS and HMFS rates of HBsAg-positive patients were 81.9% and 90.5% for patients with stage II/III BC, while those rates of HBsAg-negative patients were 88.5% and 96.3%, respectively. In stage I patients, there was no significant difference in 5-year OS (95.8% vs. 97.1%; P=0.629) and HMFS (100.0% vs. 99.0%; P=0.447).ConclusionsIn conclusion, chronic HBV infection predicts a worse prognosis in patients with stage II/III BC, but not stage I BC.
ISSN	23055839
Volume Number	8
PubMed Central reference number	PMC7154483
Issue Number	5
PubMed reference number	32309327
Journal	Annals of Translational Medicine [Ann Transl Med]
e-ISSN	23055847
DOI	10.21037/atm.2020.01.97
Language	English
Publisher	AME Publishing Company
Publisher Date	2020-03-01
Access Restriction	Open
Rights License	Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved.
Subject Keyword	Breast cancer (BC) hepatitis B virus infection (HBV infection) clinic-pathological features survival liver metastasis
Content Type	Text
Resource Type	Article
Subject	Medicine