NDLI: Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis b (2012).

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Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis b (2012).

Content Provider	CiteSeerX
Author	Kanda, Tatsuo Shinozaki, Masami Kamezaki, Hidehiro Wu, Shuang Nakamoto, Shingo Arai, Makoto Fujiwara, Keiichi Goto, Nobuaki Imazeki, Fumio Yokosuka, Osamu
Abstract	licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received: 2011.09.21; Accepted: 2011.10.31; Published: 2011.11.10 Background/Aims: Spontaneous acute exacerbation of chronic hepatitis B virus (HBV) infection occasionally occurs in its natural history, sometimes leading rapidly to fatal hepatic failure. We compared the effects of lamivudine (LAM) with those of entecavir (ETV) treatments in acute exacerbation of chronic hepatitis B with 500 IU/L or higher alanine aminotransferase (ALT) levels. Methods: Thirty-four patients with acute exacerbation were consecutively treated with LAM /ETV. Their clinical improvements were compared. Results: Among LAM-treated and ETV-treated patients, none showed a reduction of <1 log IU/mL in HBV DNA after 1 or 3 months of treatment. Initial virological response, defined as a reduction of 4 log IU/mL in HBV DNA at 6 months, with LAM and ETV, respectively, was 83.3 % and 100%. One LAM patient developed hepatic encephalopathy, but all patients in both groups survived. Twelve months after treatment, 41.6 % of 24 LAM group patients switched to
File Format	PDF
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Acute Exacerbation Chronic Hepatitis Hbv Dna Log Iu Ml Lam Patient Noncommercial Use Clinical Improvement Chronic Hepatitis Virus Etv-treated Patient Alanine Aminotransferase Thirty-four Patient Natural History Twelve Month Hepatic Failure Spontaneous Acute Exacerbation Lam Group Patient Lam Etv Initial Virological Response Hepatic Encephalopathy
Content Type	Text
Resource Type	Article

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