NDLI: Alsterpaullone induces apoptosis of HepG2 cells via a p38 mitogen-activated protein kinase signaling pathway.

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Alsterpaullone induces apoptosis of HepG2 cells via a p38 mitogen-activated protein kinase signaling pathway.

Content Provider	Europe PMC
Author	Yin, Peng Zheng, Nanxin Dong, Junfeng Xu, Chunyang Zhang, Xiaomei Ding, Guoshan
Copyright Year	2019
Abstract	Alsterpaullone (Alp) is a small-molecule inhibitor that targets cyclin-dependent kinases to inhibit tumor cell activity. However, to the best of our knowledge, the effect of Alp on hepatoblastoma has not been investigated. Therefore, the function of Alp in apoptotic induction of hepatoblastoma cells and a potential mechanism of action were investigated. Results indicated that low doses of Alp (1 µM) significantly induced apoptosis in the HepG2 hepatoblastoma cell line. In vivo experiments of tumor suppression further indicated that Alp (3 mg/kg) exerted an inhibitory effect on HepG2 ×enograft tumor growth. Following Alp treatment, the expression level of B-cell lymphoma 2 (Bcl-2)-associated X protein, and cleaved caspase-3 and −9 in HepG2 cells was significantly increased; however, the expression of Bcl-2 was significantly decreased. In addition, phosphorylation of p38 mitogen-activated protein kinase (MAPK) significantly decreased Alp-induced caspase-3 and −9 activation. These results suggested that Alp induces apoptosis and inhibited proliferation via the p38MAPK signaling pathway. Therefore, Alp may be a therapeutic agent for treating hepatoblastoma.
ISSN	17921074
Journal	Oncology Letters
Volume Number	17
PubMed Central reference number	PMC6312958
Issue Number	1
PubMed reference number	30655881
e-ISSN	17921082
DOI	10.3892/ol.2018.9700
Language	English
Publisher	D.A. Spandidos
Publisher Date	2018-11-14
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Yin et al.
Subject Keyword	alsterpaullone HepG2 cells apoptosis p38 mitogen-activated protein kinase
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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